Aldolase in Cultivated Human Fibroblasts

Barbara K. Burton; Claramma M. Chacko; Henry L. Nadler

doi:10.3181/00379727-146-38156

Aldolase in Cultivated Human Fibroblasts

Barbara K. Burton, Claramma M. Chacko, Henry L. Nadler

Pediatrics

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3 Scopus citations

Abstract

This study presents evidence that the predominant enzyme present in cultivated human fibroblasts is aldolase A. The FDP/F1P activity ratio, K_m and pH optima of the aldolase in crude fibroblast extracts are comparable to those previously described for aldolase A. No differences in activity or catalytic properties could be detected between the aldolase present in normal human fibroblasts and in fibroblasts from a patient with hereditary fructose intolerance.

Original language	English (US)
Pages (from-to)	605-607
Number of pages	3
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	146
Issue number	2
DOIs	https://doi.org/10.3181/00379727-146-38156
State	Published - Jun 1974

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Aldolase in Cultivated Human Fibroblasts",

abstract = "This study presents evidence that the predominant enzyme present in cultivated human fibroblasts is aldolase A. The FDP/F1P activity ratio, Km and pH optima of the aldolase in crude fibroblast extracts are comparable to those previously described for aldolase A. No differences in activity or catalytic properties could be detected between the aldolase present in normal human fibroblasts and in fibroblasts from a patient with hereditary fructose intolerance.",

author = "Burton, {Barbara K.} and Chacko, {Claramma M.} and Nadler, {Henry L.}",

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AU - Chacko, Claramma M.

AU - Nadler, Henry L.

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N2 - This study presents evidence that the predominant enzyme present in cultivated human fibroblasts is aldolase A. The FDP/F1P activity ratio, Km and pH optima of the aldolase in crude fibroblast extracts are comparable to those previously described for aldolase A. No differences in activity or catalytic properties could be detected between the aldolase present in normal human fibroblasts and in fibroblasts from a patient with hereditary fructose intolerance.

AB - This study presents evidence that the predominant enzyme present in cultivated human fibroblasts is aldolase A. The FDP/F1P activity ratio, Km and pH optima of the aldolase in crude fibroblast extracts are comparable to those previously described for aldolase A. No differences in activity or catalytic properties could be detected between the aldolase present in normal human fibroblasts and in fibroblasts from a patient with hereditary fructose intolerance.

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Aldolase in Cultivated Human Fibroblasts

Abstract

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