TY - JOUR
T1 - Alfentanil for short duration laparoscopic procedures
AU - Lee, K. S.
AU - Purcell, G. J.
AU - Rae, B. R.
AU - White, B.
N1 - Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - Alfentanil in low dosage (8 μg kg-1) as an analgesic agent for short duration surgery was evaluated. Forty-one women undergoing laparoscopy received double-blind either alfentanil 8 μg kg-1 or normal saline at induction, and all received thiopentone, alcuronium, enflurane, nitrous oxide and oxygen. The fall in mean arterial pressure (MAP) with induction was similar between groups. The MAP following intubation with alfentanil was unchanged, while with normal saline a mean rise of 23 (SD 15.2) mmHg occurred (P < 0.001). The pulse rate following intubation showed a smaller rise (P < 0.001) with alfentanil of 26 (SD 14.6) beats min-1, than the normal saline group of 46 (SD 13.3) beats min-1. Alfentanil was found to be a safe and effective analgesic agent in short duration surgery, by reducing sympathetic responses to intubation without cardiovascular depression or compromise of postoperative recovery.
AB - Alfentanil in low dosage (8 μg kg-1) as an analgesic agent for short duration surgery was evaluated. Forty-one women undergoing laparoscopy received double-blind either alfentanil 8 μg kg-1 or normal saline at induction, and all received thiopentone, alcuronium, enflurane, nitrous oxide and oxygen. The fall in mean arterial pressure (MAP) with induction was similar between groups. The MAP following intubation with alfentanil was unchanged, while with normal saline a mean rise of 23 (SD 15.2) mmHg occurred (P < 0.001). The pulse rate following intubation showed a smaller rise (P < 0.001) with alfentanil of 26 (SD 14.6) beats min-1, than the normal saline group of 46 (SD 13.3) beats min-1. Alfentanil was found to be a safe and effective analgesic agent in short duration surgery, by reducing sympathetic responses to intubation without cardiovascular depression or compromise of postoperative recovery.
UR - http://www.scopus.com/inward/record.url?scp=0022450282&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022450282&partnerID=8YFLogxK
U2 - 10.1177/0310057x8601400109
DO - 10.1177/0310057x8601400109
M3 - Article
C2 - 2937338
AN - SCOPUS:0022450282
SN - 0310-057X
VL - 14
SP - 37
EP - 40
JO - Anaesthesia and Intensive Care
JF - Anaesthesia and Intensive Care
IS - 1
ER -