Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

Job Boekhoven; R. Helen Zha; Faifan Tantakitti; Ellen Zhuang; Roya Zandi; Christina J. Newcomb; Samuel I. Stupp

doi:10.1039/c4ra16593d

Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

Job Boekhoven, R. Helen Zha, Faifan Tantakitti, Ellen Zhuang, Roya Zandi, Christina J. Newcomb, Samuel I. Stupp^*

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

Original language	English (US)
Pages (from-to)	8753-8756
Number of pages	4
Journal	RSC Advances
Volume	5
Issue number	12
DOIs	https://doi.org/10.1039/c4ra16593d
State	Published - 2015

ASJC Scopus subject areas

General Chemistry
General Chemical Engineering

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10.1039/c4ra16593d

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abstract = "We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.",

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AU - Boekhoven, Job

AU - Zha, R. Helen

AU - Tantakitti, Faifan

AU - Zhuang, Ellen

AU - Zandi, Roya

AU - Newcomb, Christina J.

AU - Stupp, Samuel I.

PY - 2015

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AB - We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

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Alginate-peptide amphiphile core-shell microparticles as a targeted drug delivery system

Abstract

ASJC Scopus subject areas

UN SDGs

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