Alignment and osteoarthritis of the knee

David J. Hunter, Leena Sharma, Tyler Skaife

Research output: Contribution to journalArticlepeer-review

77 Scopus citations


Osteoarthritis is widely believed to result from local mechanical factors acting within the context of systemic susceptibility. Previous studies have demonstrated that malalignment is a potent predictor of disease progression in patients with osteoarthritis of the knee. Malalignment also mediates the effects of other risk factors, including obesity, quadriceps strength, laxity, and stage of disease. Recent studies have had conflicting results regarding whether malalignment increases the risk of incident tibiofemoral osteoarthritis. While the evidence is conflicting, malalignment appears to play a smaller role in incident disease. Certain local factors within the joint, such as tibiofemoral congruence, integrity of the anteriorcruciate ligament, and meniscal degeneration and position, appear to play a role in determining alignment. It is also apparent that malalignment changes with disease progression and is itself possibly influenced by structural changes within the joint.

Original languageEnglish (US)
Pages (from-to)85-89
Number of pages5
JournalThe Journal of bone and joint surgery. American volume
Issue numberSUPPL. 1
StatePublished - Feb 1 2009

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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