Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites

Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. Objective: We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. Methods: Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. Results: PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P <.001). PedsQL-EoE reports correlated between parents and children across ages and multiple domains (r = 0.48-0.79, P <.001). There was a tight correlation between symptoms on PEESSv2.0 and their effects on QOL both on self-report and parental report (P <.001). Self-reported symptoms on PEESSv2.0 (positively) and PedsQL-EoE (inversely) showed a weak correlation with proximal, but not distal, peak eosinophil counts and features and architectural tissue changes on the EoE Histology Scoring System (P <.05). Conclusions: Parents of children with EoE aged 3 to 18 years accurately reflected their children's disease symptoms and QOL. Self- and parent-reported symptoms correlate with proximal esophageal histology. Our data suggest that parental report in young children can function as an adequate marker for self-reported symptoms and that self-reported symptoms can reflect changes in tissue histology in the proximal esophagus. These findings should be considered during clinical trials for drug development.

Original languageEnglish (US)
Pages (from-to)130-138.e1
JournalJournal of Allergy and Clinical Immunology
Volume142
Issue number1
DOIs
StatePublished - Jul 1 2018

Fingerprint

Eosinophilic Esophagitis
Histology
Quality of Life
Parents
Pediatrics
Clinical Trials
Gastrointestinal Diseases
Eosinophils
Self Report
Caregivers
Esophagus
Research Personnel

Keywords

  • Consortium of Eosinophilic Gastrointestinal Disease Researchers
  • Eosinophil
  • eosinophilic esophagitis
  • eosinophilic oesophagitis
  • patient-reported outcomes
  • pediatric QOL EoE module
  • pediatric eosinophilic esophagitis symptom score
  • quality of life
  • symptoms
  • version 2

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR). / Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. In: Journal of Allergy and Clinical Immunology. 2018 ; Vol. 142, No. 1. pp. 130-138.e1.
@article{f5f944d44ac24796a0773dda713818ce,
title = "Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites",
abstract = "Background: Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. Objective: We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. Methods: Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. Results: PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P <.001). PedsQL-EoE reports correlated between parents and children across ages and multiple domains (r = 0.48-0.79, P <.001). There was a tight correlation between symptoms on PEESSv2.0 and their effects on QOL both on self-report and parental report (P <.001). Self-reported symptoms on PEESSv2.0 (positively) and PedsQL-EoE (inversely) showed a weak correlation with proximal, but not distal, peak eosinophil counts and features and architectural tissue changes on the EoE Histology Scoring System (P <.05). Conclusions: Parents of children with EoE aged 3 to 18 years accurately reflected their children's disease symptoms and QOL. Self- and parent-reported symptoms correlate with proximal esophageal histology. Our data suggest that parental report in young children can function as an adequate marker for self-reported symptoms and that self-reported symptoms can reflect changes in tissue histology in the proximal esophagus. These findings should be considered during clinical trials for drug development.",
keywords = "Consortium of Eosinophilic Gastrointestinal Disease Researchers, Eosinophil, eosinophilic esophagitis, eosinophilic oesophagitis, patient-reported outcomes, pediatric QOL EoE module, pediatric eosinophilic esophagitis symptom score, quality of life, symptoms, version 2",
author = "{Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)} and Aceves, {Seema S.} and Eileen King and Collins, {Margaret H.} and Guang-Yu Yang and Capocelli, {Kelley E.} and Abonia, {J. Pablo} and Dan Atkins and Bonis, {Peter A.} and Carpenter, {Christina L.} and Dellon, {Evan S.} and Eby, {Michael D.} and Falk, {Gary W.} and Gonsalves, {Nirmala Prabu} and Gupta, {Sandeep K.} and Ikuo Hirano and Kendra Kocher and Krischer, {Jeffrey P.} and John Leung and Jessi Lipscomb and Paul Menard-Katcher and Mukkada, {Vincent A.} and Zhaoxing Pan and Spergel, {Jonathan M.} and Qin Sun and Wershil, {Barry K} and Rothenberg, {Marc E.} and Furuta, {Glenn T.} and Ashley Arrington and Jeanie Bailey and John Besse and Book, {Wendy M.} and Deirdre Burke and Jacquelyn Covington and Maureen DeMarschall and Ranjan Dohil and Allison Dubner and Heather Foote and Shaobo Guan and Alicia Hurnton and Ellyn Kodroff and Jonathan Kuhl and Shay Kyle and Megan Lewis and Denise Mack and Sarah McGee and Melissa Mingler and Susan Moist and Amanda Muir and Heidi Poppendeck and Wechsler, {Joshua Brian}",
year = "2018",
month = "7",
day = "1",
doi = "10.1016/j.jaci.2018.05.014",
language = "English (US)",
volume = "142",
pages = "130--138.e1",
journal = "Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Mosby Inc.",
number = "1",

}

Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites. / Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR).

In: Journal of Allergy and Clinical Immunology, Vol. 142, No. 1, 01.07.2018, p. 130-138.e1.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alignment of parent- and child-reported outcomes and histology in eosinophilic esophagitis across multiple CEGIR sites

AU - Consortium of Eosinophilic Gastrointestinal Disease Researchers (CEGIR)

AU - Aceves, Seema S.

AU - King, Eileen

AU - Collins, Margaret H.

AU - Yang, Guang-Yu

AU - Capocelli, Kelley E.

AU - Abonia, J. Pablo

AU - Atkins, Dan

AU - Bonis, Peter A.

AU - Carpenter, Christina L.

AU - Dellon, Evan S.

AU - Eby, Michael D.

AU - Falk, Gary W.

AU - Gonsalves, Nirmala Prabu

AU - Gupta, Sandeep K.

AU - Hirano, Ikuo

AU - Kocher, Kendra

AU - Krischer, Jeffrey P.

AU - Leung, John

AU - Lipscomb, Jessi

AU - Menard-Katcher, Paul

AU - Mukkada, Vincent A.

AU - Pan, Zhaoxing

AU - Spergel, Jonathan M.

AU - Sun, Qin

AU - Wershil, Barry K

AU - Rothenberg, Marc E.

AU - Furuta, Glenn T.

AU - Arrington, Ashley

AU - Bailey, Jeanie

AU - Besse, John

AU - Book, Wendy M.

AU - Burke, Deirdre

AU - Covington, Jacquelyn

AU - DeMarschall, Maureen

AU - Dohil, Ranjan

AU - Dubner, Allison

AU - Foote, Heather

AU - Guan, Shaobo

AU - Hurnton, Alicia

AU - Kodroff, Ellyn

AU - Kuhl, Jonathan

AU - Kyle, Shay

AU - Lewis, Megan

AU - Mack, Denise

AU - McGee, Sarah

AU - Mingler, Melissa

AU - Moist, Susan

AU - Muir, Amanda

AU - Poppendeck, Heidi

AU - Wechsler, Joshua Brian

PY - 2018/7/1

Y1 - 2018/7/1

N2 - Background: Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. Objective: We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. Methods: Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. Results: PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P <.001). PedsQL-EoE reports correlated between parents and children across ages and multiple domains (r = 0.48-0.79, P <.001). There was a tight correlation between symptoms on PEESSv2.0 and their effects on QOL both on self-report and parental report (P <.001). Self-reported symptoms on PEESSv2.0 (positively) and PedsQL-EoE (inversely) showed a weak correlation with proximal, but not distal, peak eosinophil counts and features and architectural tissue changes on the EoE Histology Scoring System (P <.05). Conclusions: Parents of children with EoE aged 3 to 18 years accurately reflected their children's disease symptoms and QOL. Self- and parent-reported symptoms correlate with proximal esophageal histology. Our data suggest that parental report in young children can function as an adequate marker for self-reported symptoms and that self-reported symptoms can reflect changes in tissue histology in the proximal esophagus. These findings should be considered during clinical trials for drug development.

AB - Background: Patient-reported outcome metrics for eosinophilic esophagitis (EoE) have been developed and validated but not used in a multicenter pediatric population or systematically aligned with histology. Objective: We sought to understand (1) the potential of caregiver report to predict patient self-reported symptoms and (2) the correlation of patient-reported outcome domains with histology. Methods: Patients with EoE (n = 310) and their parents participating in the Consortium of Gastrointestinal Eosinophilic Disease Researchers (CEGIR) observational clinical trial were queried for baseline patient symptoms and quality of life (QOL) by using the Pediatric Eosinophilic Esophagitis Symptom Score, version 2 (PEESSv2.0), and the Pediatric QOL EoE module (PedsQL-EoE), and biopsy specimens were analyzed by using the EoE Histology Scoring System. Results: PEESSv2.0 parental and child reports aligned across all domains (r = 0.68-0.73, P <.001). PedsQL-EoE reports correlated between parents and children across ages and multiple domains (r = 0.48-0.79, P <.001). There was a tight correlation between symptoms on PEESSv2.0 and their effects on QOL both on self-report and parental report (P <.001). Self-reported symptoms on PEESSv2.0 (positively) and PedsQL-EoE (inversely) showed a weak correlation with proximal, but not distal, peak eosinophil counts and features and architectural tissue changes on the EoE Histology Scoring System (P <.05). Conclusions: Parents of children with EoE aged 3 to 18 years accurately reflected their children's disease symptoms and QOL. Self- and parent-reported symptoms correlate with proximal esophageal histology. Our data suggest that parental report in young children can function as an adequate marker for self-reported symptoms and that self-reported symptoms can reflect changes in tissue histology in the proximal esophagus. These findings should be considered during clinical trials for drug development.

KW - Consortium of Eosinophilic Gastrointestinal Disease Researchers

KW - Eosinophil

KW - eosinophilic esophagitis

KW - eosinophilic oesophagitis

KW - patient-reported outcomes

KW - pediatric QOL EoE module

KW - pediatric eosinophilic esophagitis symptom score

KW - quality of life

KW - symptoms

KW - version 2

UR - http://www.scopus.com/inward/record.url?scp=85049074301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85049074301&partnerID=8YFLogxK

U2 - 10.1016/j.jaci.2018.05.014

DO - 10.1016/j.jaci.2018.05.014

M3 - Article

C2 - 29852258

AN - SCOPUS:85049074301

VL - 142

SP - 130-138.e1

JO - Journal of Allergy and Clinical Immunology

JF - Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 1

ER -