Abstract
Insulin resistance is the main cause of type 2 diabetes. Polysaccharide is one of the main active components in mushrooms. Some mushroom polysaccharides have been reported to have beneficial effects against type 2 diabetes. However, the structural features and mechanisms of polysaccharides with hypoglycemic activity have not been elucidated. In this paper, six alkali-soluble total polysaccharides, six neutral polysaccharides and six acidic polysaccharides were extracted and purified from mushrooms fruiting bodies of different species. The effects of these polysaccharides on improving insulin resistance were compared using high fatty acids and glucose-induced hepatocytes. Among them, the neutral polysaccharide AAMP-N of Armillaria mellea fruiting body showed the most significant activity, indicating that mannogalactoglucan is the main active domain. AAMP-N enhanced insulin sensitivity in vitro. Also AAMP-N lowered blood glucose, and modulated lipid metabolism in db/db mice. In addition, AAMP-N protected damaged pancreatic islets in mice. Our results demonstrated the role of natural polysaccharides from mushrooms in the improvement of insulin sensitivity and lipid metabolism, and provided basis for the development of mushroom polysaccharides as hypoglycemic healthy food.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 466-474 |
| Number of pages | 9 |
| Journal | International Journal of Biological Macromolecules |
| Volume | 126 |
| DOIs | |
| State | Published - Apr 1 2019 |
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Keywords
- Insulin resistance
- Mushrooms polysaccharides
- Type 2 diabetes
ASJC Scopus subject areas
- Structural Biology
- Biochemistry
- Molecular Biology
- Economics and Econometrics
- Energy(all)
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Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance. / Yang, Siwen; Yan, Jingmin; Yang, Lulu; Meng, Yuhan; Wang, Na; He, Congcong; Fan, Yuying; Zhou, Yifa.
In: International Journal of Biological Macromolecules, Vol. 126, 01.04.2019, p. 466-474.Research output: Contribution to journal › Article
TY - JOUR
T1 - Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance
AU - Yang, Siwen
AU - Yan, Jingmin
AU - Yang, Lulu
AU - Meng, Yuhan
AU - Wang, Na
AU - He, Congcong
AU - Fan, Yuying
AU - Zhou, Yifa
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Insulin resistance is the main cause of type 2 diabetes. Polysaccharide is one of the main active components in mushrooms. Some mushroom polysaccharides have been reported to have beneficial effects against type 2 diabetes. However, the structural features and mechanisms of polysaccharides with hypoglycemic activity have not been elucidated. In this paper, six alkali-soluble total polysaccharides, six neutral polysaccharides and six acidic polysaccharides were extracted and purified from mushrooms fruiting bodies of different species. The effects of these polysaccharides on improving insulin resistance were compared using high fatty acids and glucose-induced hepatocytes. Among them, the neutral polysaccharide AAMP-N of Armillaria mellea fruiting body showed the most significant activity, indicating that mannogalactoglucan is the main active domain. AAMP-N enhanced insulin sensitivity in vitro. Also AAMP-N lowered blood glucose, and modulated lipid metabolism in db/db mice. In addition, AAMP-N protected damaged pancreatic islets in mice. Our results demonstrated the role of natural polysaccharides from mushrooms in the improvement of insulin sensitivity and lipid metabolism, and provided basis for the development of mushroom polysaccharides as hypoglycemic healthy food.
AB - Insulin resistance is the main cause of type 2 diabetes. Polysaccharide is one of the main active components in mushrooms. Some mushroom polysaccharides have been reported to have beneficial effects against type 2 diabetes. However, the structural features and mechanisms of polysaccharides with hypoglycemic activity have not been elucidated. In this paper, six alkali-soluble total polysaccharides, six neutral polysaccharides and six acidic polysaccharides were extracted and purified from mushrooms fruiting bodies of different species. The effects of these polysaccharides on improving insulin resistance were compared using high fatty acids and glucose-induced hepatocytes. Among them, the neutral polysaccharide AAMP-N of Armillaria mellea fruiting body showed the most significant activity, indicating that mannogalactoglucan is the main active domain. AAMP-N enhanced insulin sensitivity in vitro. Also AAMP-N lowered blood glucose, and modulated lipid metabolism in db/db mice. In addition, AAMP-N protected damaged pancreatic islets in mice. Our results demonstrated the role of natural polysaccharides from mushrooms in the improvement of insulin sensitivity and lipid metabolism, and provided basis for the development of mushroom polysaccharides as hypoglycemic healthy food.
KW - Insulin resistance
KW - Mushrooms polysaccharides
KW - Type 2 diabetes
UR - http://www.scopus.com/inward/record.url?scp=85059324397&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85059324397&partnerID=8YFLogxK
U2 - 10.1016/j.ijbiomac.2018.12.251
DO - 10.1016/j.ijbiomac.2018.12.251
M3 - Article
C2 - 30594618
AN - SCOPUS:85059324397
VL - 126
SP - 466
EP - 474
JO - International Journal of Biological Macromolecules
JF - International Journal of Biological Macromolecules
SN - 0141-8130
ER -