Abstract
Insulin resistance is the main cause of type 2 diabetes. Polysaccharide is one of the main active components in mushrooms. Some mushroom polysaccharides have been reported to have beneficial effects against type 2 diabetes. However, the structural features and mechanisms of polysaccharides with hypoglycemic activity have not been elucidated. In this paper, six alkali-soluble total polysaccharides, six neutral polysaccharides and six acidic polysaccharides were extracted and purified from mushrooms fruiting bodies of different species. The effects of these polysaccharides on improving insulin resistance were compared using high fatty acids and glucose-induced hepatocytes. Among them, the neutral polysaccharide AAMP-N of Armillaria mellea fruiting body showed the most significant activity, indicating that mannogalactoglucan is the main active domain. AAMP-N enhanced insulin sensitivity in vitro. Also AAMP-N lowered blood glucose, and modulated lipid metabolism in db/db mice. In addition, AAMP-N protected damaged pancreatic islets in mice. Our results demonstrated the role of natural polysaccharides from mushrooms in the improvement of insulin sensitivity and lipid metabolism, and provided basis for the development of mushroom polysaccharides as hypoglycemic healthy food.
Original language | English (US) |
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Pages (from-to) | 466-474 |
Number of pages | 9 |
Journal | International Journal of Biological Macromolecules |
Volume | 126 |
DOIs | |
State | Published - Apr 1 2019 |
Funding
This work was supported by National Natural Science Foundation of China (No. 31872674 ), Scientific and Technologic Foundation of Jilin Province (No. 20180311068YY ), Jilin Province Development and Reform Commission (No. 2018C047-2 ), and Fundamental Research Funds for the Central Universities (No. 2412017FZ018 ).
Keywords
- Insulin resistance
- Mushrooms polysaccharides
- Type 2 diabetes
ASJC Scopus subject areas
- General Energy
- Economics and Econometrics
- Molecular Biology
- Structural Biology
- Biochemistry