Alkali-soluble polysaccharides from mushroom fruiting bodies improve insulin resistance

Siwen Yang, Jingmin Yan, Lulu Yang, Yuhan Meng, Na Wang, Congcong He, Yuying Fan*, Yifa Zhou

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations


Insulin resistance is the main cause of type 2 diabetes. Polysaccharide is one of the main active components in mushrooms. Some mushroom polysaccharides have been reported to have beneficial effects against type 2 diabetes. However, the structural features and mechanisms of polysaccharides with hypoglycemic activity have not been elucidated. In this paper, six alkali-soluble total polysaccharides, six neutral polysaccharides and six acidic polysaccharides were extracted and purified from mushrooms fruiting bodies of different species. The effects of these polysaccharides on improving insulin resistance were compared using high fatty acids and glucose-induced hepatocytes. Among them, the neutral polysaccharide AAMP-N of Armillaria mellea fruiting body showed the most significant activity, indicating that mannogalactoglucan is the main active domain. AAMP-N enhanced insulin sensitivity in vitro. Also AAMP-N lowered blood glucose, and modulated lipid metabolism in db/db mice. In addition, AAMP-N protected damaged pancreatic islets in mice. Our results demonstrated the role of natural polysaccharides from mushrooms in the improvement of insulin sensitivity and lipid metabolism, and provided basis for the development of mushroom polysaccharides as hypoglycemic healthy food.

Original languageEnglish (US)
Pages (from-to)466-474
Number of pages9
JournalInternational Journal of Biological Macromolecules
StatePublished - Apr 1 2019


  • Insulin resistance
  • Mushrooms polysaccharides
  • Type 2 diabetes

ASJC Scopus subject areas

  • General Energy
  • Economics and Econometrics
  • Molecular Biology
  • Structural Biology
  • Biochemistry


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