All Aboard: Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy

J. W. Kim*, J. Murphy, A. L. Chang, D. A. Spencer, J. R. Kane, D. Kanojia, A. Rashidi, J. S. Young, M. S. Lesniak

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Modern virotherapy for the potential treatment of a wide array of human diseases, including cancer, has been investigated for its capacity to elicit therapeutic benefits by way of alterable genetic modification. And while immediate gains in the field have demonstrated pronounced efficacy in therapeutic potential, endogenous and preexisting neutralizing antibody responses hinder the delivery of these vectors. Even more so in the case of cancer therapeutic potential, limited biodistribution of such viral particles within the bulk of the tumor mass is observed. To circumvent these adversities in the delivery of a viral vector to the site of pathology, mesenchymal stem/stromal cells may be used to avoid immune stimulation with resultant vector clearance, to maximize the effective delivery potential, and to augment biodistribution ability in neoplastic tumor masses.

Original languageEnglish (US)
Title of host publicationMesenchymal Stromal Cells as Tumor Stromal Modulators
PublisherElsevier Inc
Pages475-499
Number of pages25
ISBN (Electronic)9780128031032
ISBN (Print)9780128031025
DOIs
Publication statusPublished - Nov 18 2016

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Keywords

  • Cancer therapy
  • Delivery vehicle
  • Mesenchymal stem/stromal cell
  • Oncolytic viruses
  • Tumor tropism

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Kim, J. W., Murphy, J., Chang, A. L., Spencer, D. A., Kane, J. R., Kanojia, D., ... Lesniak, M. S. (2016). All Aboard: Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy. In Mesenchymal Stromal Cells as Tumor Stromal Modulators (pp. 475-499). Elsevier Inc. https://doi.org/10.1016/B978-0-12-803102-5.00019-7