All Aboard: Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy

J. W. Kim; J. Murphy; A. L. Chang; D. A. Spencer; J. R. Kane; D. Kanojia; A. Rashidi; J. S. Young; M. S. Lesniak

doi:10.1016/B978-0-12-803102-5.00019-7

All Aboard: Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy

J. W. Kim^*, J. Murphy, A. L. Chang, D. A. Spencer, J. R. Kane, D. Kanojia, A. Rashidi, J. S. Young, M. S. Lesniak

^*Corresponding author for this work

Neurological Surgery

Research output: Chapter in Book/Report/Conference proceeding › Chapter

1 Scopus citations

Abstract

Modern virotherapy for the potential treatment of a wide array of human diseases, including cancer, has been investigated for its capacity to elicit therapeutic benefits by way of alterable genetic modification. And while immediate gains in the field have demonstrated pronounced efficacy in therapeutic potential, endogenous and preexisting neutralizing antibody responses hinder the delivery of these vectors. Even more so in the case of cancer therapeutic potential, limited biodistribution of such viral particles within the bulk of the tumor mass is observed. To circumvent these adversities in the delivery of a viral vector to the site of pathology, mesenchymal stem/stromal cells may be used to avoid immune stimulation with resultant vector clearance, to maximize the effective delivery potential, and to augment biodistribution ability in neoplastic tumor masses.

Original language	English (US)
Title of host publication	Mesenchymal Stromal Cells as Tumor Stromal Modulators
Publisher	Elsevier Inc
Pages	475-499
Number of pages	25
ISBN (Electronic)	9780128031032
ISBN (Print)	9780128031025
DOIs	https://doi.org/10.1016/B978-0-12-803102-5.00019-7
State	Published - Nov 18 2016

Keywords

Cancer therapy
Delivery vehicle
Mesenchymal stem/stromal cell
Oncolytic viruses
Tumor tropism

ASJC Scopus subject areas

Medicine(all)
Biochemistry, Genetics and Molecular Biology(all)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/B978-0-12-803102-5.00019-7

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title = "All Aboard: Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy",

abstract = "Modern virotherapy for the potential treatment of a wide array of human diseases, including cancer, has been investigated for its capacity to elicit therapeutic benefits by way of alterable genetic modification. And while immediate gains in the field have demonstrated pronounced efficacy in therapeutic potential, endogenous and preexisting neutralizing antibody responses hinder the delivery of these vectors. Even more so in the case of cancer therapeutic potential, limited biodistribution of such viral particles within the bulk of the tumor mass is observed. To circumvent these adversities in the delivery of a viral vector to the site of pathology, mesenchymal stem/stromal cells may be used to avoid immune stimulation with resultant vector clearance, to maximize the effective delivery potential, and to augment biodistribution ability in neoplastic tumor masses.",

keywords = "Cancer therapy, Delivery vehicle, Mesenchymal stem/stromal cell, Oncolytic viruses, Tumor tropism",

author = "Kim, {J. W.} and J. Murphy and Chang, {A. L.} and Spencer, {D. A.} and Kane, {J. R.} and D. Kanojia and A. Rashidi and Young, {J. S.} and Lesniak, {M. S.}",

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T2 - Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy

AU - Kim, J. W.

AU - Murphy, J.

AU - Chang, A. L.

AU - Spencer, D. A.

AU - Kane, J. R.

AU - Kanojia, D.

AU - Rashidi, A.

AU - Young, J. S.

AU - Lesniak, M. S.

PY - 2016/11/18

Y1 - 2016/11/18

N2 - Modern virotherapy for the potential treatment of a wide array of human diseases, including cancer, has been investigated for its capacity to elicit therapeutic benefits by way of alterable genetic modification. And while immediate gains in the field have demonstrated pronounced efficacy in therapeutic potential, endogenous and preexisting neutralizing antibody responses hinder the delivery of these vectors. Even more so in the case of cancer therapeutic potential, limited biodistribution of such viral particles within the bulk of the tumor mass is observed. To circumvent these adversities in the delivery of a viral vector to the site of pathology, mesenchymal stem/stromal cells may be used to avoid immune stimulation with resultant vector clearance, to maximize the effective delivery potential, and to augment biodistribution ability in neoplastic tumor masses.

AB - Modern virotherapy for the potential treatment of a wide array of human diseases, including cancer, has been investigated for its capacity to elicit therapeutic benefits by way of alterable genetic modification. And while immediate gains in the field have demonstrated pronounced efficacy in therapeutic potential, endogenous and preexisting neutralizing antibody responses hinder the delivery of these vectors. Even more so in the case of cancer therapeutic potential, limited biodistribution of such viral particles within the bulk of the tumor mass is observed. To circumvent these adversities in the delivery of a viral vector to the site of pathology, mesenchymal stem/stromal cells may be used to avoid immune stimulation with resultant vector clearance, to maximize the effective delivery potential, and to augment biodistribution ability in neoplastic tumor masses.

KW - Cancer therapy

KW - Delivery vehicle

KW - Mesenchymal stem/stromal cell

KW - Oncolytic viruses

KW - Tumor tropism

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M3 - Chapter

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SN - 9780128031025

SP - 475

EP - 499

BT - Mesenchymal Stromal Cells as Tumor Stromal Modulators

PB - Elsevier Inc

ER -

All Aboard: Mesenchymal Stem/Stromal Cells as Cell Carriers for Virotherapy

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

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