All or none block of single Na+ channels by tetrodotoxin

Fred N. Quandt*, J. Z. Yeh, T. Narahashi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


The effects of tetrodotoxin on single Na+-channel currents recorded from excised patches of neuroblastoma cells were examined. Tetrodotoxin was found to cause a dose-dependent reduction in the frequency at which Na+ channels conduct during a series of depolarizations. Surviving conducting states had normal open times and current amplitudes. These effects could be explained by a model which includes initial binding of tetrodotoxin to a closed state of the channel with stable, complete block during the time the channel would normally be gated open.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalNeuroscience Letters
Issue number1
StatePublished - 1985


  • channel blocker
  • neuroblastoma
  • patch clamp
  • single-channel analysis
  • sodium channel
  • tetrodotoxin

ASJC Scopus subject areas

  • Neuroscience(all)


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