Abstract
Background: Using genetic scores for fasting plasma glucose (FPG GS) and type 2 diabetes (T2D GS), we investigated whether the fasting, 1-hour and 2-hour glucose thresholds from the WHO 2013 criteria for gestational diabetes (GDM) have different implications for genetic susceptibility to raised fasting glucose and type 2 diabetes in women from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) and Atlantic Diabetes in Pregnancy (DIP) studies. Methods: Cases were divided into three subgroups: (i) FPG ≥5.1 mmol/L only, n=222; (ii) 1-hour glucose post 75 g oral glucose load ≥10 mmol/L only, n=154 (iii) 2-hour glucose ≥8.5 mmol/L only, n=73; and (iv) both FPG ≥5.1 mmol/L and either of a 1-hour glucose ≥10 mmol/L glucose ≥8.5 mmol/L, n=172. We compared the FPG and T2D GS of these groups with controls (n=3,091) in HAPO and DIP separately. Results: In HAPO and DIP, the mean FPG GS in women with a FPG ≥5.1 mmol/L, either on its own or with 1-hour glucose ≥10 mmol/L or 2-hour glucose ≥8.5 mmol/L, was higher than controls (all P <0.01). Mean T2D GS in women with a raised FPG alone or with either a raised 1-hour or 2-hour glucose was higher than controls (all P <0.05). GDM defined by 1-hour or 2-hour hyperglycaemia only was also associated with a higher T2D GS than controls (all P <0.05). Conclusions: The different diagnostic categories that are part of the predisposition to type 2 diabetes as well as a risk for adverse pregnancy outcomes.
Original language | English (US) |
---|---|
Pages (from-to) | 1-28 |
Number of pages | 28 |
Journal | Wellcome Open Research |
Volume | 5 |
DOIs | |
State | Published - 2020 |
Funding
Grant information: This work was supported by Wellcome [GW4 Clinical Academic Training PhD Fellowship to AEH; 110082, Postdoctoral Training Fellowship to KAP; 104150, a Wellcome and Royal Society Sir Henry Dale Fellowship to RMF; 088541, a Sir Henry Wellcome Postdoctoral Fellowship to RMF was used to fund genotyping of the SNPs in HAPO and DIP]. AEH was also funded by the National Institute of Health Research (NIHR). ATH is a Wellcome Trust Senior Investigator (098395) and NIHR senior investigator. HAPO was supported by grants from Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD-34242 and HD-32423), National Human Genome Research Institute (HG-004415), the National Institute of Diabetes and Digestive and Kidney Diseases (DK-DK097534) and the American Diabetes Association. DIP was supported by grants from the Ireland Health Research Board.
Keywords
- Gestational diabetes
- fasting plasma glucose
- genetic scores
- type 2 diabetes
ASJC Scopus subject areas
- Medicine (miscellaneous)
- General Biochemistry, Genetics and Molecular Biology