Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians

Igal Ifergan*, Nicole F. Bernard, Julie Bruneau, Michel Alary, Christos M. Tsoukas, Michel Roger

*Corresponding author for this work

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.

Original languageEnglish (US)
Pages (from-to)2340-2342
Number of pages3
JournalAIDS
Volume16
Issue number17
DOIs
StatePublished - Nov 22 2002

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

Fingerprint Dive into the research topics of 'Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians'. Together they form a unique fingerprint.

  • Cite this