Abstract
Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2340-2342 |
| Number of pages | 3 |
| Journal | AIDS |
| Volume | 16 |
| Issue number | 17 |
| DOIs | |
| State | Published - Nov 22 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases
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Ifergan, I., Bernard, N. F., Bruneau, J., Alary, M., Tsoukas, C. M., & Roger, M. (2002). Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians. AIDS, 16(17), 2340-2342. https://doi.org/10.1097/00002030-200211220-00017