Abstract
Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.
Original language | English (US) |
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Pages (from-to) | 2340-2342 |
Number of pages | 3 |
Journal | AIDS |
Volume | 16 |
Issue number | 17 |
DOIs | |
State | Published - Nov 22 2002 |
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
- Infectious Diseases