Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians

Igal Ifergan; Nicole F. Bernard; Julie Bruneau; Michel Alary; Christos M. Tsoukas; Michel Roger

doi:10.1097/00002030-200211220-00017

Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians

Igal Ifergan^*, Nicole F. Bernard, Julie Bruneau, Michel Alary, Christos M. Tsoukas, Michel Roger

^*Corresponding author for this work

Microbiology-Immunology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.

Original language	English (US)
Pages (from-to)	2340-2342
Number of pages	3
Journal	AIDS
Volume	16
Issue number	17
DOIs	https://doi.org/10.1097/00002030-200211220-00017
State	Published - Nov 22 2002

ASJC Scopus subject areas

Immunology and Allergy
Immunology
Infectious Diseases

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abstract = "Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.",

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AU - Ifergan, Igal

AU - Bernard, Nicole F.

AU - Bruneau, Julie

AU - Alary, Michel

AU - Tsoukas, Christos M.

AU - Roger, Michel

PY - 2002/11/22

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AB - Recent data suggest that MDR-1 expression may affect HIV-1 infectivity by modulating the immune response and its cellular permissiveness. We investigated whether three functional MDR-1 polymorphims (T-129C, G2677T/A, C3435T) were associated with the risk of infection in 137 Caucasians highly exposed to HIV (70 infected and 67 uninfected). There was no difference in allelic frequencies for each MDR-1 polymorphic site among both groups. This finding suggests that P-glycoprotein expression does not influence HIV-1 infection per se.

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Allele frequency of three functionally active polymorphisms of the MDR-1 gene in high-risk HIV-negative and HIV-positive Caucasians

Abstract

ASJC Scopus subject areas

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