Abstract
Hypersensitivity pneumonitis (HP) has been typically described in the context of acute or chronic disease. Immediate cutaneous reactivity to Aspergillus species indicates the presence of Aspergillus-specific IgE antibodies and occurs in approximately 25-28% of patients with asthma. It is unknown whether Aspergillus-sensitized patients with asthma have an altered natural history, as compared with patients with asthma and sensitization to other fungal allergens. Patients with allergic fungal sinusitis have a history of chronic sinusitis, nasal polyps, recurrences of purulent sinusitis despite medical and surgical interventions, and sinus radiography demonstrates opacified sinuses. HP presents as acute, subacute, or chronic disease. Chronic HP also may be insidious and results in pulmonary fibrosis to the point of honeycombing on CXR, dyspnea, and eventually respiratory failure. Pulmonary function tests show a restrictive pattern with varying degrees of obstruction, sometimes resembling asthma.
Original language | English (US) |
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Title of host publication | Inflammatory Mechanisms in Allergic Diseases |
Publisher | CRC Press |
Pages | 449-468 |
Number of pages | 20 |
ISBN (Electronic) | 9781420029291 |
ISBN (Print) | 9780824705404 |
DOIs | |
State | Published - Jan 1 2023 |
ASJC Scopus subject areas
- General Medicine