Allergic Bronchopulmonary Aspergillosis, Allergic Fungal Sinusitis, and Hypersensitivity Pneumonitis

Paul A. Greenberger*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hypersensitivity pneumonitis (HP) has been typically described in the context of acute or chronic disease. Immediate cutaneous reactivity to Aspergillus species indicates the presence of Aspergillus-specific IgE antibodies and occurs in approximately 25-28% of patients with asthma. It is unknown whether Aspergillus-sensitized patients with asthma have an altered natural history, as compared with patients with asthma and sensitization to other fungal allergens. Patients with allergic fungal sinusitis have a history of chronic sinusitis, nasal polyps, recurrences of purulent sinusitis despite medical and surgical interventions, and sinus radiography demonstrates opacified sinuses. HP presents as acute, subacute, or chronic disease. Chronic HP also may be insidious and results in pulmonary fibrosis to the point of honeycombing on CXR, dyspnea, and eventually respiratory failure. Pulmonary function tests show a restrictive pattern with varying degrees of obstruction, sometimes resembling asthma.

Original languageEnglish (US)
Title of host publicationInflammatory Mechanisms in Allergic Diseases
PublisherCRC Press
Pages449-468
Number of pages20
ISBN (Electronic)9781420029291
ISBN (Print)9780824705404
DOIs
StatePublished - Jan 1 2023

ASJC Scopus subject areas

  • General Medicine

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