Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis - State of the Art: Cystic Fibrosis Foundation Consensus Conference

David A. Stevens*, Richard B. Moss, Viswanath P. Kurup, Alan P. Knutsen, Paul Greenberger, Marc A. Judson, David W. Denning, Reto Crameri, Alan S. Brody, Michael Light, Marianne Skov, William Maish, Gianni Mastella

*Corresponding author for this work

Research output: Contribution to journalArticle

507 Scopus citations

Abstract

Because of the difficulties of recognizing allergic bronchopulmonary aspergillosis (ABPA) in the context of cystic fibrosis (because of overlapping clinical, radiographic, microbiologic, and immunologic features), advances in our understanding of the pathogenesis of allergic aspergillosis, new possibilities in therapy, and the need for agreed-upon definitions, an international consensus conference was convened. Areas addressed included fungal biology, immunopathogenesis, insights from animal models, diagnostic criteria, epidemiology, the use of new immunologic and genetic techniques in diagnosis, imaging modalities, pharmacology, and treatment approaches. Evidence from the existing literature was graded, and the consensus views were synthesized into this document and recirculated for affirmation. Virulence factors in Aspergillus that could aggravate these diseases, and particularly immunogenetic factors that could predispose persons to ABPA, were identified. New information has come from transgenic animals and recombinant fungal and host molecules. Diagnostic criteria that could provide a framework for monitoring were adopted, and helpful imaging features were identified. New possibilities in therapy produced plans for managing diverse clinical presentations.

Original languageEnglish (US)
Pages (from-to)S225-S264
JournalClinical Infectious Diseases
Volume37
Issue numberSUPPL. 3
DOIs
StatePublished - Oct 1 2003

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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    Stevens, D. A., Moss, R. B., Kurup, V. P., Knutsen, A. P., Greenberger, P., Judson, M. A., Denning, D. W., Crameri, R., Brody, A. S., Light, M., Skov, M., Maish, W., & Mastella, G. (2003). Allergic Bronchopulmonary Aspergillosis in Cystic Fibrosis - State of the Art: Cystic Fibrosis Foundation Consensus Conference. Clinical Infectious Diseases, 37(SUPPL. 3), S225-S264. https://doi.org/10.1086/376525