Allergic bronchopulmonary candidiasis: Case report and suggested diagnostic criteria

Theodore M. Lee, Paul A. Greenberger*, Soo Oh, Roy Patterson, Mary Roberts, Janice L. Liotta

*Corresponding author for this work

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

A patient with an illness consistent with allergic bronchopulmonary candidiasis is described. The patient had asthma, atelectatic pulmonary infiltrates on three occasions, immediate cutaneous reactivity as low as 10-7 (wt/vol) to Candida albicans extract, and precipitating antibody to this organism. C. albicans was the only organism cultured from two bronchial lavage specimens. Total serum IgE was elevated to 5745 ng/ml and decreased rapidly with corticosteroid therapy. Serologic studies were not consistent with allergic bronchopulmonary aspergillosis. Serum IgE to C. albicans, measured by ELISA after adsorption of IgG from the serum samples by incubation with staphylococcal protein A, was found to be 575% to 650% above control values. The serum IgE antibody activity against Candida decreased with clinical improvement after corticosteroid therapy.

Original languageEnglish (US)
Pages (from-to)816-820
Number of pages5
JournalThe Journal of Allergy and Clinical Immunology
Volume80
Issue number6
DOIs
StatePublished - Dec 1987

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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