Allergic mechanisms in eosinophilic esophagitis

Joshua B. Wechsler, Paul J. Bryce*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

31 Scopus citations

Abstract

Eosinophilic esophagitis is rapidly increasing in incidence. It is associated with food antigen-triggered, eosinophil-predominant inflammation, and the pathogenic mechanisms have many similarities to other chronic atopic diseases. Studies in animal models and from patients have suggested that allergic sensitization leads to food-specific IgE and T-helper lymphocyte type 2 cells, both of which seem to contribute to the pathogenesis along with basophils, mast cells, and antigen-presenting cells. In this review our current understandings of the allergic mechanisms that drive eosinophilic esophagitis are outlined, drawing from clinical and translational studies in humans as well as experimental animal models.

Original languageEnglish (US)
Pages (from-to)281-296
Number of pages16
JournalGastroenterology Clinics of North America
Volume43
Issue number2
DOIs
StatePublished - Jun 2014

Keywords

  • Allergic mechanism
  • Antigen sensitization
  • Atopic
  • Eosinophilic esophagitis
  • Pathogenesis
  • T-helper lymphocyte type 2 immunity

ASJC Scopus subject areas

  • Gastroenterology

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