Allergic reactions to streptokinase consistent with anaphylactic or antigen-antibody complex-mediated damage

Kris G. McGrath; Barry Zeffren; Jay Alexander; Kerry Kaplan; Roy Patterson

doi:10.1016/0091-6749(85)90726-2

Allergic reactions to streptokinase consistent with anaphylactic or antigen-antibody complex-mediated damage

Kris G. McGrath, Barry Zeffren, Jay Alexander, Kerry Kaplan, Roy Patterson^*

^*Corresponding author for this work

Medicine, Allergy Division

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Streptokinase used as a thrombolytic agent may produce immunologic drug reactions. We report a second case of IgE-mediated anaphylaxis and a late reaction to streptokinase. This late reaction was consistent with an IgG-mediated antigen-antibody disease with transient renal involvement, fever, and cutaneous lesions. The second case responded to prednisone therapy.

Original language	English (US)
Pages (from-to)	453-457
Number of pages	5
Journal	The Journal of allergy and clinical immunology
Volume	76
Issue number	3
DOIs	https://doi.org/10.1016/0091-6749(85)90726-2
State	Published - Sep 1985

Funding

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1016/0091-6749(85)90726-2

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title = "Allergic reactions to streptokinase consistent with anaphylactic or antigen-antibody complex-mediated damage",

abstract = "Streptokinase used as a thrombolytic agent may produce immunologic drug reactions. We report a second case of IgE-mediated anaphylaxis and a late reaction to streptokinase. This late reaction was consistent with an IgG-mediated antigen-antibody disease with transient renal involvement, fever, and cutaneous lesions. The second case responded to prednisone therapy.",

author = "McGrath, {Kris G.} and Barry Zeffren and Jay Alexander and Kerry Kaplan and Roy Patterson",

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AU - McGrath, Kris G.

AU - Zeffren, Barry

AU - Alexander, Jay

AU - Kaplan, Kerry

AU - Patterson, Roy

PY - 1985/9

Y1 - 1985/9

N2 - Streptokinase used as a thrombolytic agent may produce immunologic drug reactions. We report a second case of IgE-mediated anaphylaxis and a late reaction to streptokinase. This late reaction was consistent with an IgG-mediated antigen-antibody disease with transient renal involvement, fever, and cutaneous lesions. The second case responded to prednisone therapy.

AB - Streptokinase used as a thrombolytic agent may produce immunologic drug reactions. We report a second case of IgE-mediated anaphylaxis and a late reaction to streptokinase. This late reaction was consistent with an IgG-mediated antigen-antibody disease with transient renal involvement, fever, and cutaneous lesions. The second case responded to prednisone therapy.

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Allergic reactions to streptokinase consistent with anaphylactic or antigen-antibody complex-mediated damage

Abstract

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ASJC Scopus subject areas

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