Allogeneic bone marrow transplantation for Alexander's disease

M. J. Staba; S. Goldman; F. L. Johnson; P. R. Huttenlocher

doi:10.1038/sj.bmt.1700871

Allogeneic bone marrow transplantation for Alexander's disease

M. J. Staba^*, S. Goldman, F. L. Johnson, P. R. Huttenlocher

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander's disease. Based on research that describes Alexander's disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the patient's neurological deterioration. Despite an initial return to her pretransplant neurological state, the patients neurological status deteriorated. Marrow transplantation was not effective in changing her prognosis with Alexander's disease.

Original language	English (US)
Pages (from-to)	247-249
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	20
Issue number	3
DOIs	https://doi.org/10.1038/sj.bmt.1700871
State	Published - Aug 1 1997

Keywords

Alexander's disease
AlloBMT
Leukodystrophy

ASJC Scopus subject areas

Hematology
Transplantation

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10.1038/sj.bmt.1700871

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abstract = "In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander's disease. Based on research that describes Alexander's disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the patient's neurological deterioration. Despite an initial return to her pretransplant neurological state, the patients neurological status deteriorated. Marrow transplantation was not effective in changing her prognosis with Alexander's disease.",

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AB - In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander's disease. Based on research that describes Alexander's disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the patient's neurological deterioration. Despite an initial return to her pretransplant neurological state, the patients neurological status deteriorated. Marrow transplantation was not effective in changing her prognosis with Alexander's disease.

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KW - Leukodystrophy

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Allogeneic bone marrow transplantation for Alexander's disease

Abstract

Keywords

ASJC Scopus subject areas

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