Allogeneic bone marrow transplantation for Alexander's disease

M. J. Staba*, S. Goldman, F. L. Johnson, P. R. Huttenlocher

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


In this case report, we evaluate the efficacy of allogeneic bone marrow transplantation (BMT) in a 7-month-old female with the infantile form of Alexander's disease. Based on research that describes Alexander's disease as a leukodystrophy which may result from an unidentified enzyme deficiency, we attempted marrow transplantation to reverse or arrest the patient's neurological deterioration. Despite an initial return to her pretransplant neurological state, the patients neurological status deteriorated. Marrow transplantation was not effective in changing her prognosis with Alexander's disease.

Original languageEnglish (US)
Pages (from-to)247-249
Number of pages3
JournalBone Marrow Transplantation
Issue number3
StatePublished - Aug 1 1997


  • Alexander's disease
  • AlloBMT
  • Leukodystrophy

ASJC Scopus subject areas

  • Hematology
  • Transplantation


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