Genes controlling rabbit immunoglobulin heavy chains are the V(H)a, V(H)x, and V(H)y genes for the variable regions and C(γ)de, C(α)f, C(α)g and C(γ)n for the constant regions. These genes are closely linked. In family studies, using allotypic specificities as the genetic markers, at least 6 haploid sets of these genes have been found to cosegregate as Mendelian units and are called allogroups. The recognition of these allogroups is important for studies of antibody diversity and the chromosomal mapping of immunoglobulin genes.
|Original language||English (US)|
|Number of pages||7|
|State||Published - Jan 1 1974|
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