Allopeptides and the alloimmune response

Ankit Bharat, T. Mohanakumar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

The inherent ability of the host immune system to distinguish between self- and non-self forms the basis of allorecognition. T lymphocytes constitute the most important effector arm of allorecognition. Here we describe the fundamentals of direct and indirect pathways by which allopeptides are presented to effector T cells. The nature of allopeptides presented along with tolerogenic strategies like altered peptide ligands and intra- or extra-thymic allopeptide inoculation are discussed. In addition, we speculate on the potential of regulatory T cells to modulate alloimmune responses.

Original languageEnglish (US)
Pages (from-to)31-43
Number of pages13
JournalCellular Immunology
Volume248
Issue number1
DOIs
StatePublished - Jul 2007

Keywords

  • Alloimmune response
  • Allopeptides
  • MHC antigens
  • Regulatory T cells
  • Rejection
  • Tolerance

ASJC Scopus subject areas

  • Immunology

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