Abstract
The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.
Original language | English (US) |
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Pages (from-to) | 13252-13255 |
Number of pages | 4 |
Journal | Journal of the American Chemical Society |
Volume | 137 |
Issue number | 41 |
DOIs | |
State | Published - Oct 21 2015 |
ASJC Scopus subject areas
- Catalysis
- Chemistry(all)
- Biochemistry
- Colloid and Surface Chemistry
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CCDC 1418334: Experimental Crystal Structure Determination
Henkelis, J. J. (Creator), Blackburn, A. K. (Creator), Dale, E. J. (Creator), Vermeulen, N. A. (Creator), Nassar, M. S. (Creator) & Stoddart, J. F. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc1jlwqq, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1jlwqq&sid=DataCite
Dataset
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CCDC 1418336: Experimental Crystal Structure Determination
Henkelis, J. J. (Creator), Blackburn, A. K. (Creator), Dale, E. J. (Creator), Vermeulen, N. A. (Creator), Nassar, M. S. (Creator) & Stoddart, J. F. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc1jlwss, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1jlwss&sid=DataCite
Dataset
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CCDC 1418335: Experimental Crystal Structure Determination
Henkelis, J. J. (Creator), Blackburn, A. K. (Creator), Dale, E. J. (Creator), Vermeulen, N. A. (Creator), Nassar, M. S. (Creator) & Stoddart, J. F. (Creator), Cambridge Crystallographic Data Centre, 2015
DOI: 10.5517/cc1jlwrr, http://www.ccdc.cam.ac.uk/services/structure_request?id=doi:10.5517/cc1jlwrr&sid=DataCite
Dataset