Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

James J. Henkelis; Anthea K. Blackburn; Edward J. Dale; Nicolaas A. Vermeulen; Majed S. Nassar; J. Fraser Stoddart

doi:10.1021/jacs.5b08656

Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

James J. Henkelis, Anthea K. Blackburn, Edward J. Dale, Nicolaas A. Vermeulen, Majed S. Nassar, J. Fraser Stoddart^*

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.

Original language	English (US)
Pages (from-to)	13252-13255
Number of pages	4
Journal	Journal of the American Chemical Society
Volume	137
Issue number	41
DOIs	https://doi.org/10.1021/jacs.5b08656
State	Published - Oct 21 2015

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/jacs.5b08656

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title = "Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor",

abstract = "The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.",

author = "Henkelis, {James J.} and Blackburn, {Anthea K.} and Dale, {Edward J.} and Vermeulen, {Nicolaas A.} and Nassar, {Majed S.} and Stoddart, {J. Fraser}",

note = "Publisher Copyright: {\textcopyright} 2015 American Chemical Society.",

year = "2015",

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T1 - Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

AU - Henkelis, James J.

AU - Blackburn, Anthea K.

AU - Dale, Edward J.

AU - Vermeulen, Nicolaas A.

AU - Nassar, Majed S.

AU - Stoddart, J. Fraser

PY - 2015/10/21

Y1 - 2015/10/21

N2 - The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.

AB - The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.

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JF - Journal of the American Chemical Society

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Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

Abstract

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CCDC 1418334: Experimental Crystal Structure Determination

CCDC 1418336: Experimental Crystal Structure Determination

CCDC 1418335: Experimental Crystal Structure Determination

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Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

Abstract

ASJC Scopus subject areas

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Datasets

CCDC 1418334: Experimental Crystal Structure Determination

CCDC 1418336: Experimental Crystal Structure Determination

CCDC 1418335: Experimental Crystal Structure Determination

Cite this