Allosteric Modulation of Substrate Binding within a Tetracationic Molecular Receptor

James J. Henkelis, Anthea K. Blackburn, Edward J. Dale, Nicolaas A. Vermeulen, Majed S. Nassar, J. Fraser Stoddart*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


The synthesis and recognition phenomena of a tetracationic molecular receptor that possesses a nanometer-sized molecular cavity are described. The host-guest properties of the molecular receptor can be tuned and modulated allosterically, where the association of a heterotropic effector at the periphery of the molecule serves to modulate its affinity for the globular, electron-rich guest that resides within its molecular cavity. This stimuli-responsive host-guest behavior was observed in both the solution phase and the crystalline solid state, and can be reversed with high fidelity by sequestration of the effector molecule.

Original languageEnglish (US)
Pages (from-to)13252-13255
Number of pages4
JournalJournal of the American Chemical Society
Issue number41
StatePublished - Oct 21 2015

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry


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