Alpha-chlorofatty acid and coronary artery or aorta calcium scores in women with systemic lupus erythematosus. A pilot study

Mary A. Mahieu, Camelia P. Guild, Carolyn J. Albert, George T. Kondos, James J. Carr, Daniel Edmundowicz, David A. Ford, Rosalind Ramsey-Goldman

Research output: Contribution to journalArticle

Abstract

Objective. Alpha-chlorofatty acid (α-ClFA) is one product of myeloperoxidase activity in vivo during atherogenesis and may be a biomarker for cardiovascular disease (CVD). We investigated if serum α-ClFA is associated with subclinical CVD as measured by coronary artery and aorta calcium scores (CAC and AC, respectively) in women with and without systemic lupus erythematosus (SLE). Methods. This pilot project analyzed baseline data from 173 women with SLE and 186 women without SLE participating in a 5-year longitudinal investigation of the Study of Lupus Vascular and Bone Long-term Endpoints (SOLVABLE). Data collection included demographic information, CVD and SLE risk factors, and laboratory assessments. Alpha-ClFA was measured in stored serum by liquid chromatography-mass spectrometry. CAC and AC were measured by computed tomography. Outcome measures were CAC and AC present (CAC > 0 or AC > 0) versus absent (CAC = 0 or AC = 0). Associations between risk factors and CAC or AC were tested with descriptive statistics and multivariate analyses. Results. Women with SLE had higher α-ClFA levels than women without SLE (42.0 fmol/25 μl ± 37.3 vs 34.5 fmol/25 μl ± 21.9; p = 0.020). In analyses including individual CVD risk factors, having SLE was independently associated with the presence of CAC (OR 3.42, 95% CI 1.72 to 6.78) but not AC. Alpha-ClFA was not associated with the presence of CAC or AC in patients with SLE. Conclusion. SLE, but not serum α-ClFA, was associated with the presence of CAC in this pilot project.

Original languageEnglish (US)
Pages (from-to)1834-1842
Number of pages9
JournalJournal of Rheumatology
Volume41
Issue number9
DOIs
StatePublished - Jan 1 2014

Keywords

  • Aorta calcium copyright
  • Cardiovascular disease coronary artery calcium
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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