Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use

Hilal A. Lashuel; D. James Surmeier; Tanya Simuni; Kalpana Merchant; Byron Caughey; Claudio Soto; Mohamed Bilal Fares; Roland G. Heym; Ronald Melki

doi:10.1126/sciadv.adt7195

Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use

Hilal A. Lashuel^*, D. James Surmeier, Tanya Simuni, Kalpana Merchant, Byron Caughey, Claudio Soto, Mohamed Bilal Fares, Roland G. Heym, Ronald Melki

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Alpha-synuclein seed amplification assays can improve neurodegenerative disease diagnosis and care, but widespread use depends on a framework that standardizes protocols and encourages data sharing.

Original language	English (US)
Article number	eadt7195
Journal	Science Advances
Volume	11
Issue number	14
DOIs	https://doi.org/10.1126/sciadv.adt7195
State	Published - Apr 4 2025

Funding

We would like to thank G. Limorenko for support in producing the original Fig. 1 and all the funding agencies that supported their work on the aSyn-SAAs: D.J.S. (JPB Foundation and NIH); B.C. (Division of Intramural Research of the NIAID); H.A.L., C.S., T.S., R.G.H., and K.M. (MJFF); and R.M. (Fondation pour la Recherche M\u00E9dicale).

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title = "Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use",

abstract = "Alpha-synuclein seed amplification assays can improve neurodegenerative disease diagnosis and care, but widespread use depends on a framework that standardizes protocols and encourages data sharing.",

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AU - Caughey, Byron

AU - Soto, Claudio

AU - Fares, Mohamed Bilal

AU - Heym, Roland G.

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Alpha-synuclein seed amplification assays: Data sharing, standardization needed for clinical use

Abstract

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