ALS: Management Problems

Jonathan R. Brent, Colin K. Franz, John M. Coleman, Senda Ajroud-Driss*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Amyotrophic lateral sclerosis (ALS) is a fatal disease with no cure; however, symptomatic management has an impact on quality of life and survival. Symptom management is best performed in a multidisciplinary care setting, where patients are evaluated by multiple health care professionals. Respiratory failure is a significant cause of morbidity and mortality in patients with ALS. Early initiation of noninvasive ventilation can prolong survival, and adequate use of airway clearance techniques can prevent respiratory infections. Preventing and treating weight loss caused by dysphagia may slow down disease progression, and expert management of spasticity from upper motor neuron dysfunction enhances patient well-being.

Original languageEnglish (US)
Pages (from-to)565-575
Number of pages11
JournalNeurologic clinics
Volume38
Issue number3
DOIs
StatePublished - Aug 2020

Keywords

  • ALS
  • Dysarthria
  • Dysphagia
  • Noninvasive ventilation
  • Respiratory failure
  • Secretion management
  • Sialorrhea
  • Spasticity

ASJC Scopus subject areas

  • Clinical Neurology

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