Alteration in fluid mechanics in femoral arteries with atheroma development

Y. Liu*, A. Nagaraj, A. Hamilton, Kiang Liu, Li Jing Yan, D. D. McPherson, K. B. Chandran

*Corresponding author for this work

Research output: Contribution to journalConference article

Abstract

The relationship between regional alterations in wall motion, normalized wall shear amplitude (NWSA), and atheromatic lesion composition was evaluated in the Yucatan miniswine model with developing atherosclerosis. We induced vascular lesions by endothelial cell denudation. The animals were fed a high cholesterol diet for 8 weeks to develop early atherosclerotic lesions. At the end of the 8 weeks, hemodynamic and intravascular ultrasound (IVUS) image data were obtained in both the denuded and control femoral arteries. The vascular segment geometry was reconstructed from the imaging data and the CFD analysis performed in each segment incorporating the vascular wall motion data obtained from the images as a moving boundary condition. NWSA was correlated with vessel wall motion and lesion composition. Data from 6 control and 4 diseased arteries were analyzed. Results demonstrate that wall motion and NWSA increased in arterial segment with atheroma compared to those in healthy region, as determined from histology. However, the wall motion in the diseased segments demonstrated regional variability compared to relatively uniform distribution in the healthy segments. This study demonstrates the regional variability in the wall motion and NWSA in vascular segments in the presence of early atheroma compared to those in healthy segments.

Original languageEnglish (US)
Pages (from-to)1287-1288
Number of pages2
JournalAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
StatePublished - Dec 1 2002
EventProceedings of the 2002 IEEE Engineering in Medicine and Biology 24th Annual Conference and the 2002 Fall Meeting of the Biomedical Engineering Society (BMES / EMBS) - Houston, TX, United States
Duration: Oct 23 2002Oct 26 2002

Keywords

  • Atheroma
  • NWSA
  • Wall distensibility

ASJC Scopus subject areas

  • Signal Processing
  • Biomedical Engineering
  • Computer Vision and Pattern Recognition
  • Health Informatics

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