Alteration in fluid mechanics in porcine femoral arteries with atheroma development

Yutong Liu, Andrew Hamilton, Ashwin Nagaraj, Lijing L. Yan, Kiang Liu, Yong Gen Lai, David D. McPherson, Krishnan B. Chandran*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Although the relationship between the local wall shear stresses (WSS) and atheroma development has been previously studied, the effect of variable regional wall distensibility with early atherosclerotic lesions and its effect on local hemodynamics have not been well investigated. We induced early atherosclerotic lesion development in one femoral artery in a Yucatan miniswine model with the contralateral artery serving as control. Eight weeks following atheroma formation, hemodynamic and intravascular ultrasound image data were obtained. Using the measured regional arterial distension as the moving boundary condition, unsteady laminar incompressible computational analysis was performed on the reconstructed arterial segments. With the development of early atherosclerotic lesions, there was increased wall distensibility and an increase in the computed normalized wall shear stress amplitude (NWSA). Alterations in the local fluid mechanics and mass transport at these sites may need to be considered in our understanding of the continued growth of these lesions.

Original languageEnglish (US)
Pages (from-to)544-554
Number of pages11
JournalAnnals of Biomedical Engineering
Issue number4
StatePublished - Apr 2004


  • Early atherosclerotic lesions
  • Normalized wall shear amplitude
  • Regional wall distensibility

ASJC Scopus subject areas

  • Biomedical Engineering


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