Alteration of Membrane Compositional Asymmetry by LiCoO2 Nanosheets

Merve Doʇangün, Mimi N. Hang, Julianne M. Troiano, Alicia C. McGeachy, Eric S. Melby, Joel A. Pedersen, Robert J. Hamers, Franz M. Geiger*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

32 Scopus citations

Abstract

Given the projected massive presence of redox-active nanomaterials in the next generation of consumer electronics and electric vehicle batteries, they are likely to eventually come in contact with cell membranes, with biological consequences that are currently not known. Here, we present nonlinear optical studies showing that lithium nickel manganese cobalt oxide nanosheets carrying a negative ζ-potential have no discernible consequences for lipid alignment and interleaflet composition in supported lipid bilayers formed from zwitterionic and negatively charged lipids. In contrast, lithiated and delithiated LiCoO2 nanosheets having positive and neutral ζ-potentials, respectively, alter the compositional asymmetry of the two membrane leaflets, and bilayer asymmetry remains disturbed even after rinsing. The insight that some cobalt oxide nanoformulations induce alterations to the compositional asymmetry in idealized model membranes may represent an important step toward assessing the biological consequences of their predicted widespread use.

Original languageEnglish (US)
Pages (from-to)8755-8765
Number of pages11
JournalACS nano
Volume9
Issue number9
DOIs
StatePublished - Sep 22 2015

Keywords

  • nano-bio interface
  • phospholipid bilayer asymmetry
  • secondary ion mass spectrometry
  • silica/water interfaces
  • sum-frequency generation
  • transbilayer movement

ASJC Scopus subject areas

  • Materials Science(all)
  • Engineering(all)
  • Physics and Astronomy(all)

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