Alterations in plasma dipeptidyl peptidase IV enzyme activity in depression and schizophrenia: Effects of antidepressants and antipsychotic drugs

M. Maes*, I. De Meester, S. Scharpé, R. Desnyder, R. Ranjan, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

42 Scopus citations

Abstract

Recently, our laboratory reported that the activity of dipeptidyl-peptidase IV (DPP IV) was significantly lower in the peripheral blood of major depressed patients than in normal controls. The present study examines plasma DPP IV activity in 43 major depressed and 13 schizophrenic subjects versus 21 normal controls and the effects of antidepressants and antipsychotic drugs on plasma DPP IV activity. DPP IV activity was significantly lower in major depressed subjects than in normal controls and schizophrenic subjects. There was a trend towards higher DPP IV activity in schizophrenic patients than in normal controls. There were no significant effects of antidepressants or neuroleptics on plasma DPP IV activity in depressed and schizophrenic patients, respectively. There were no significant relationships between plasma DPP IV activity and plasma cortisol or immune-inflammatory markers, such as serum interleukin-6 (IL-6) or soluble IL-2 receptor. A significant and positive correlation was found between plasma DPP IV and prolyl endopeptidase (PEP) enzyme activity in the study group as a whole and in schizophrenic subjects. The results support the hypothesis that lower and higher plasma DPP IV activities are trait markers of major depression and schizophrenia, respectively. It is concluded that alterations in the enzyme activity of peptidases, such as DPP IV and PEP, play a role in the pathophysiology of major depression and schizophrenia.

Original languageEnglish (US)
Pages (from-to)1-8
Number of pages8
JournalActa Psychiatrica Scandinavica
Volume93
Issue number1
DOIs
StatePublished - 1996

Keywords

  • Antidepressant drug
  • Depression
  • Neuroleptic drug
  • Peptides
  • Schizophrenia

ASJC Scopus subject areas

  • Psychiatry and Mental health

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