Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons

M Matthew Oh, Fernando A. Oliveira, Jack Waters, John F Disterhoft

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

Altered neuronal calcium homeostasis is widely hypothesized to underlie cognitive deficits in normal aging subjects, but the mechanisms that underlie this change are unknown, possibly due to a paucity of direct measurements from aging neurons. UsingCCDand two-photon calcium imaging techniques on CA1 pyramidal neurons from young and aged rats, we show that calcium influx across the plasma membrane increases with aging, and that this change is countered by increased intracellular calcium buffering. The additional buffer in aging neurons balances the increased calcium influx following a small number (<3) action potentials, but is overwhelmed during sustained or theta-like activity which leads to a greater rise in intracellular calcium concentration in aging than that in young neurons. Our results demonstrate that calcium overload occurs regularly in aging CA1 pyramidal neurons under physiological conditions. This overload may be a critical factor in age-related decline in hippocampus-dependent cognitive function.

Original languageEnglish (US)
Pages (from-to)7905-7911
Number of pages7
JournalJournal of Neuroscience
Volume33
Issue number18
DOIs
StatePublished - May 10 2013

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Pyramidal Cells
Calcium
Neurons
Age Factors
Photons
Cognition
Action Potentials
Hippocampus
Buffers
Homeostasis
Cell Membrane

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Oh, M Matthew ; Oliveira, Fernando A. ; Waters, Jack ; Disterhoft, John F. / Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons. In: Journal of Neuroscience. 2013 ; Vol. 33, No. 18. pp. 7905-7911.
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Altered calcium metabolism in aging CA1 hippocampal pyramidal neurons. / Oh, M Matthew; Oliveira, Fernando A.; Waters, Jack; Disterhoft, John F.

In: Journal of Neuroscience, Vol. 33, No. 18, 10.05.2013, p. 7905-7911.

Research output: Contribution to journalArticle

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