Abstract
Our goal in the current study was to further investigate the late neurodevelopmental hypothesis of schizophrenia by examining cross-sectional, age-related changes in cognitive function among young adult (a) siblings of individuals with schizophrenia (n = 66), (b) healthy control subjects (n = 77), and (c) the siblings of healthy control subjects (n = 77). All subjects participated in a battery of tasks in four domains: verbal IQ, working memory, episodic memory, and executive function. We found significant group differences in the relationships between age and performance in working memory and episodic memory, with similar patterns for executive function and verbal IQ. The siblings of individuals with schizophrenia showed impaired performance in working memory, episodic memory, and executive function. In addition, healthy control subjects and their siblings showed age-related improvements in all four cognitive domains, whereas the siblings of individuals with schizophrenia showed this result for verbal IQ only.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 138-151 |
| Number of pages | 14 |
| Journal | Clinical Psychological Science |
| Volume | 2 |
| Issue number | 2 |
| DOIs | |
| State | Published - Mar 2014 |
Funding
Funding for this study was provided by National Institute of Mental Health Grants P50-MH071616 and R01-MH56584.
Keywords
- Cognition and emotion
- Developmental psychopathology
- Schizophrenia
ASJC Scopus subject areas
- Clinical Psychology