Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States

Ravi Kalhan; Khalid Puthawala; Smita Agarwal; Saeid B. Amini; Satish C. Kalhan

doi:10.1053/meta.2001.26704

Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States

Ravi Kalhan, Khalid Puthawala, Smita Agarwal, Saeid B. Amini, Satish C. Kalhan

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

66 Scopus citations

Abstract

South Asians who immigrate to the United States have a propensity toward insulin resistance, central obesity, and elevated total cholesterol:high-density lipoprotein (HDL) ratio. To evaluate whether these alterations are apparent at a younger age, we studied 32 offspring of South Asian immigrants and compared them with 29 of European descent between 18 to 30 years of age. American-born South Asian males had significantly higher total cholesterol, low-density lipoprotein (TC:LDL) ratios, triglycerides, and fasting insulin levels (13.9 ± 7.1 and 10.0 ± 5.5 μU/mL, P <.01) than their European counterparts. The South Asian females only had increased plasma insulin levels (15.3 ± 8.8 and 10.0 ± 5.1 μU/mL, P =.05). The entire South Asian group had higher truncal skinfold thickness (40.1 ± 18.1 and 30.3 ± 12.6 mm, P = <.05) and lower insulin-like growth factor binding protein (IGFBP)-1 levels (46.8 ± 33.4 and 56.0 ± 33.4 μg/L, P =.05). Plasma leptin levels were also significantly higher in both males (4.3 ± 2.5 v 2.8 ± 1.3 ng/mL, P =.0001) and females (20.5 ± 10.3 v 10.3 ± 6.3 ng/mL, P =.002) South Asian subjects. A significant correlation between plasma leptin and insulin, triglycerides, TC, and body mass index (BMI) was seen in the South Asian males. South Asians born in the United States show evidence for an altered metabolic profile in young adulthood. The relative contributions of inheritance and nutritional practices early in life to this alteration remain unclear.

Original language	English (US)
Pages (from-to)	1197-1202
Number of pages	6
Journal	Metabolism: Clinical and Experimental
Volume	50
Issue number	10
DOIs	https://doi.org/10.1053/meta.2001.26704
State	Published - Oct 2001

Funding

From the Robert Schwartz MD Center for Metabolism and Nutrition and General Clinical Research Center, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH. Submitted November 21, 2000; accepted March 13, 2001. Supported by General Clinical Researach Center (GCRC) Grant No. RR00080 from the National Institutes of Health. Address reprint requests to Satish Kalhan, MD, Schwartz Center, BG-774, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109. Copyright © 2001 by W.B. Saunders Company 0026-0495/01/5010-0004$35.00/0 doi:10.1053/meta.2001.26704

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1053/meta.2001.26704

Cite this

@article{b0975ad3fd99412c81b000ea1ecac98d,

title = "Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States",

abstract = "South Asians who immigrate to the United States have a propensity toward insulin resistance, central obesity, and elevated total cholesterol:high-density lipoprotein (HDL) ratio. To evaluate whether these alterations are apparent at a younger age, we studied 32 offspring of South Asian immigrants and compared them with 29 of European descent between 18 to 30 years of age. American-born South Asian males had significantly higher total cholesterol, low-density lipoprotein (TC:LDL) ratios, triglycerides, and fasting insulin levels (13.9 ± 7.1 and 10.0 ± 5.5 μU/mL, P <.01) than their European counterparts. The South Asian females only had increased plasma insulin levels (15.3 ± 8.8 and 10.0 ± 5.1 μU/mL, P =.05). The entire South Asian group had higher truncal skinfold thickness (40.1 ± 18.1 and 30.3 ± 12.6 mm, P = <.05) and lower insulin-like growth factor binding protein (IGFBP)-1 levels (46.8 ± 33.4 and 56.0 ± 33.4 μg/L, P =.05). Plasma leptin levels were also significantly higher in both males (4.3 ± 2.5 v 2.8 ± 1.3 ng/mL, P =.0001) and females (20.5 ± 10.3 v 10.3 ± 6.3 ng/mL, P =.002) South Asian subjects. A significant correlation between plasma leptin and insulin, triglycerides, TC, and body mass index (BMI) was seen in the South Asian males. South Asians born in the United States show evidence for an altered metabolic profile in young adulthood. The relative contributions of inheritance and nutritional practices early in life to this alteration remain unclear.",

author = "Ravi Kalhan and Khalid Puthawala and Smita Agarwal and Amini, {Saeid B.} and Kalhan, {Satish C.}",

note = "Funding Information: From the Robert Schwartz MD Center for Metabolism and Nutrition and General Clinical Research Center, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH. Submitted November 21, 2000; accepted March 13, 2001. Supported by General Clinical Researach Center (GCRC) Grant No. RR00080 from the National Institutes of Health. Address reprint requests to Satish Kalhan, MD, Schwartz Center, BG-774, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109. Copyright {\textcopyright} 2001 by W.B. Saunders Company 0026-0495/01/5010-0004$35.00/0 doi:10.1053/meta.2001.26704 Copyright: Copyright 2018 Elsevier B.V., All rights reserved.",

year = "2001",

month = oct,

doi = "10.1053/meta.2001.26704",

language = "English (US)",

volume = "50",

pages = "1197--1202",

journal = "Metabolism: Clinical and Experimental",

issn = "0026-0495",

publisher = "W.B. Saunders",

number = "10",

}

TY - JOUR

T1 - Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States

AU - Kalhan, Ravi

AU - Puthawala, Khalid

AU - Agarwal, Smita

AU - Amini, Saeid B.

AU - Kalhan, Satish C.

N1 - Funding Information: From the Robert Schwartz MD Center for Metabolism and Nutrition and General Clinical Research Center, Case Western Reserve University School of Medicine at MetroHealth Medical Center, Cleveland, OH. Submitted November 21, 2000; accepted March 13, 2001. Supported by General Clinical Researach Center (GCRC) Grant No. RR00080 from the National Institutes of Health. Address reprint requests to Satish Kalhan, MD, Schwartz Center, BG-774, MetroHealth Medical Center, 2500 MetroHealth Dr, Cleveland, OH 44109. Copyright © 2001 by W.B. Saunders Company 0026-0495/01/5010-0004$35.00/0 doi:10.1053/meta.2001.26704 Copyright: Copyright 2018 Elsevier B.V., All rights reserved.

PY - 2001/10

Y1 - 2001/10

N2 - South Asians who immigrate to the United States have a propensity toward insulin resistance, central obesity, and elevated total cholesterol:high-density lipoprotein (HDL) ratio. To evaluate whether these alterations are apparent at a younger age, we studied 32 offspring of South Asian immigrants and compared them with 29 of European descent between 18 to 30 years of age. American-born South Asian males had significantly higher total cholesterol, low-density lipoprotein (TC:LDL) ratios, triglycerides, and fasting insulin levels (13.9 ± 7.1 and 10.0 ± 5.5 μU/mL, P <.01) than their European counterparts. The South Asian females only had increased plasma insulin levels (15.3 ± 8.8 and 10.0 ± 5.1 μU/mL, P =.05). The entire South Asian group had higher truncal skinfold thickness (40.1 ± 18.1 and 30.3 ± 12.6 mm, P = <.05) and lower insulin-like growth factor binding protein (IGFBP)-1 levels (46.8 ± 33.4 and 56.0 ± 33.4 μg/L, P =.05). Plasma leptin levels were also significantly higher in both males (4.3 ± 2.5 v 2.8 ± 1.3 ng/mL, P =.0001) and females (20.5 ± 10.3 v 10.3 ± 6.3 ng/mL, P =.002) South Asian subjects. A significant correlation between plasma leptin and insulin, triglycerides, TC, and body mass index (BMI) was seen in the South Asian males. South Asians born in the United States show evidence for an altered metabolic profile in young adulthood. The relative contributions of inheritance and nutritional practices early in life to this alteration remain unclear.

AB - South Asians who immigrate to the United States have a propensity toward insulin resistance, central obesity, and elevated total cholesterol:high-density lipoprotein (HDL) ratio. To evaluate whether these alterations are apparent at a younger age, we studied 32 offspring of South Asian immigrants and compared them with 29 of European descent between 18 to 30 years of age. American-born South Asian males had significantly higher total cholesterol, low-density lipoprotein (TC:LDL) ratios, triglycerides, and fasting insulin levels (13.9 ± 7.1 and 10.0 ± 5.5 μU/mL, P <.01) than their European counterparts. The South Asian females only had increased plasma insulin levels (15.3 ± 8.8 and 10.0 ± 5.1 μU/mL, P =.05). The entire South Asian group had higher truncal skinfold thickness (40.1 ± 18.1 and 30.3 ± 12.6 mm, P = <.05) and lower insulin-like growth factor binding protein (IGFBP)-1 levels (46.8 ± 33.4 and 56.0 ± 33.4 μg/L, P =.05). Plasma leptin levels were also significantly higher in both males (4.3 ± 2.5 v 2.8 ± 1.3 ng/mL, P =.0001) and females (20.5 ± 10.3 v 10.3 ± 6.3 ng/mL, P =.002) South Asian subjects. A significant correlation between plasma leptin and insulin, triglycerides, TC, and body mass index (BMI) was seen in the South Asian males. South Asians born in the United States show evidence for an altered metabolic profile in young adulthood. The relative contributions of inheritance and nutritional practices early in life to this alteration remain unclear.

UR - http://www.scopus.com/inward/record.url?scp=0034757834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034757834&partnerID=8YFLogxK

U2 - 10.1053/meta.2001.26704

DO - 10.1053/meta.2001.26704

M3 - Article

C2 - 11586493

AN - SCOPUS:0034757834

SN - 0026-0495

VL - 50

SP - 1197

EP - 1202

JO - Metabolism: Clinical and Experimental

JF - Metabolism: Clinical and Experimental

IS - 10

ER -

Altered lipid profile, leptin, insulin, and anthropometry in offspring of South Asian immigrants in the United States

Abstract

Funding

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this