Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection

Sahera Dirajlal-Fargo, David P. Maison, Jared C. Durieux, Anastasia Andrukhiv, Nicholas Funderburg, Kate Ailstock, Mariana Gerschenson*, Grace A. Mccomsey

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p ≤ 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the etiology of PASC.

Original languageEnglish (US)
Article number101849
JournalMitochondrion
Volume75
DOIs
StatePublished - Mar 2024
Externally publishedYes

Keywords

  • COVID
  • Long COVID
  • Mitochondria
  • PASC

ASJC Scopus subject areas

  • Molecular Medicine
  • Molecular Biology
  • Cell Biology

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