Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy

Arleen Li, Alexander Ruh, Haben Berhane, Joshua D. Robinson, Michael Markl, Cynthia K. Rigsby*

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Background: Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective: To systematically compare tissue phase mapping and feature tracking for assessing regional LV function in children and young adults with HCM and pediatric controls, and to evaluate structure–function relationships among myocardial velocities, LV wall thickness and myocardial T1. Materials and methods: Seventeen pediatric patients with HCM and 21 age-matched controls underwent cardiac MRI including standard cine imaging, tissue phase mapping (two-dimensional cine phase contrast with three-directional velocity encoding), and modified Look-Locker inversion recovery to calculate native global LV T1. Maximum LV wall thickness was measured on cine images. LV radial, circumferential and long-axis myocardial velocity time courses, as well as global and segmental systolic and diastolic peak velocities, were quantified from tissue phase mapping and feature tracking. Results: Both tissue phase mapping and feature tracking detected significantly decreased global and segmental diastolic radial and long-axis peak velocities (by 12–51%, P<0.001–0.05) in pediatric patients with HCM vs. controls. Feature tracking peak velocities were lower than directly measured tissue phase mapping velocities (mean bias = 0.3–2.9 cm/s). Diastolic global peak velocities correlated moderately with global T1 (r = −0.57 to −0.72, P<0.01) and maximum wall thickness (r = −0.37 to −0.61, P<0.05). Conclusion: Both tissue phase mapping and feature tracking detected myocardial velocity changes in children and young adults with HCM vs. controls. Associations between impaired diastolic LV velocities and elevated T1 indicate structure–function relationships in HCM.

Original languageEnglish (US)
JournalPediatric radiology
DOIs
StateAccepted/In press - Jan 1 2019

Fingerprint

Hypertrophic Cardiomyopathy
Pediatrics
Young Adult
Sudden Death
Left Ventricular Function
Stroke Volume
Atrial Fibrillation
Fibrosis
Heart Failure

Keywords

  • Children
  • Feature tracking
  • Heart
  • Hypertrophic cardiomyopathy
  • Left ventricle
  • Magnetic resonance imaging
  • Myocardial velocity
  • Myocardium
  • Tissue phase mapping

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Radiology Nuclear Medicine and imaging

Cite this

@article{ec3d0bd1c57f4037b542820058201e53,
title = "Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy",
abstract = "Background: Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective: To systematically compare tissue phase mapping and feature tracking for assessing regional LV function in children and young adults with HCM and pediatric controls, and to evaluate structure–function relationships among myocardial velocities, LV wall thickness and myocardial T1. Materials and methods: Seventeen pediatric patients with HCM and 21 age-matched controls underwent cardiac MRI including standard cine imaging, tissue phase mapping (two-dimensional cine phase contrast with three-directional velocity encoding), and modified Look-Locker inversion recovery to calculate native global LV T1. Maximum LV wall thickness was measured on cine images. LV radial, circumferential and long-axis myocardial velocity time courses, as well as global and segmental systolic and diastolic peak velocities, were quantified from tissue phase mapping and feature tracking. Results: Both tissue phase mapping and feature tracking detected significantly decreased global and segmental diastolic radial and long-axis peak velocities (by 12–51{\%}, P<0.001–0.05) in pediatric patients with HCM vs. controls. Feature tracking peak velocities were lower than directly measured tissue phase mapping velocities (mean bias = 0.3–2.9 cm/s). Diastolic global peak velocities correlated moderately with global T1 (r = −0.57 to −0.72, P<0.01) and maximum wall thickness (r = −0.37 to −0.61, P<0.05). Conclusion: Both tissue phase mapping and feature tracking detected myocardial velocity changes in children and young adults with HCM vs. controls. Associations between impaired diastolic LV velocities and elevated T1 indicate structure–function relationships in HCM.",
keywords = "Children, Feature tracking, Heart, Hypertrophic cardiomyopathy, Left ventricle, Magnetic resonance imaging, Myocardial velocity, Myocardium, Tissue phase mapping",
author = "Arleen Li and Alexander Ruh and Haben Berhane and Robinson, {Joshua D.} and Michael Markl and Rigsby, {Cynthia K.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1007/s00247-019-04549-4",
language = "English (US)",
journal = "Pediatric Radiology",
issn = "0301-0449",
publisher = "Springer Verlag",

}

TY - JOUR

T1 - Altered regional myocardial velocities by tissue phase mapping and feature tracking in pediatric patients with hypertrophic cardiomyopathy

AU - Li, Arleen

AU - Ruh, Alexander

AU - Berhane, Haben

AU - Robinson, Joshua D.

AU - Markl, Michael

AU - Rigsby, Cynthia K.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Background: Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective: To systematically compare tissue phase mapping and feature tracking for assessing regional LV function in children and young adults with HCM and pediatric controls, and to evaluate structure–function relationships among myocardial velocities, LV wall thickness and myocardial T1. Materials and methods: Seventeen pediatric patients with HCM and 21 age-matched controls underwent cardiac MRI including standard cine imaging, tissue phase mapping (two-dimensional cine phase contrast with three-directional velocity encoding), and modified Look-Locker inversion recovery to calculate native global LV T1. Maximum LV wall thickness was measured on cine images. LV radial, circumferential and long-axis myocardial velocity time courses, as well as global and segmental systolic and diastolic peak velocities, were quantified from tissue phase mapping and feature tracking. Results: Both tissue phase mapping and feature tracking detected significantly decreased global and segmental diastolic radial and long-axis peak velocities (by 12–51%, P<0.001–0.05) in pediatric patients with HCM vs. controls. Feature tracking peak velocities were lower than directly measured tissue phase mapping velocities (mean bias = 0.3–2.9 cm/s). Diastolic global peak velocities correlated moderately with global T1 (r = −0.57 to −0.72, P<0.01) and maximum wall thickness (r = −0.37 to −0.61, P<0.05). Conclusion: Both tissue phase mapping and feature tracking detected myocardial velocity changes in children and young adults with HCM vs. controls. Associations between impaired diastolic LV velocities and elevated T1 indicate structure–function relationships in HCM.

AB - Background: Hypertrophic cardiomyopathy (HCM) is associated with heart failure, atrial fibrillation and sudden death. Reduced myocardial function has been reported in HCM despite normal left ventricular (LV) ejection fraction. Additionally, LV fibrosis is associated with elevated T1 and might be an outcome predictor. Objective: To systematically compare tissue phase mapping and feature tracking for assessing regional LV function in children and young adults with HCM and pediatric controls, and to evaluate structure–function relationships among myocardial velocities, LV wall thickness and myocardial T1. Materials and methods: Seventeen pediatric patients with HCM and 21 age-matched controls underwent cardiac MRI including standard cine imaging, tissue phase mapping (two-dimensional cine phase contrast with three-directional velocity encoding), and modified Look-Locker inversion recovery to calculate native global LV T1. Maximum LV wall thickness was measured on cine images. LV radial, circumferential and long-axis myocardial velocity time courses, as well as global and segmental systolic and diastolic peak velocities, were quantified from tissue phase mapping and feature tracking. Results: Both tissue phase mapping and feature tracking detected significantly decreased global and segmental diastolic radial and long-axis peak velocities (by 12–51%, P<0.001–0.05) in pediatric patients with HCM vs. controls. Feature tracking peak velocities were lower than directly measured tissue phase mapping velocities (mean bias = 0.3–2.9 cm/s). Diastolic global peak velocities correlated moderately with global T1 (r = −0.57 to −0.72, P<0.01) and maximum wall thickness (r = −0.37 to −0.61, P<0.05). Conclusion: Both tissue phase mapping and feature tracking detected myocardial velocity changes in children and young adults with HCM vs. controls. Associations between impaired diastolic LV velocities and elevated T1 indicate structure–function relationships in HCM.

KW - Children

KW - Feature tracking

KW - Heart

KW - Hypertrophic cardiomyopathy

KW - Left ventricle

KW - Magnetic resonance imaging

KW - Myocardial velocity

KW - Myocardium

KW - Tissue phase mapping

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U2 - 10.1007/s00247-019-04549-4

DO - 10.1007/s00247-019-04549-4

M3 - Article

C2 - 31659403

AN - SCOPUS:85074653379

JO - Pediatric Radiology

JF - Pediatric Radiology

SN - 0301-0449

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