Altered responses to serotonergic agents in Fawn-Hooded rats

Gary A. Gudelsky*, James I. Koenig, Herbert Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

The incidence of "wet dog" shakes elicited by quipazine, the hyperthermic response induced by 5-methoxy-N,N-dimethyltryptamine (5MeODMT) and the hypothermic response to 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) were compared in rats of the Fawn-Hooded (FH) and Sprague-Dawley (SD) strains. The behavioral responses of FH rats to quipazine and 5MeODMT were significantly greater than those of SD rats. On the other hand, the hypothermic effect of 8-OH-DPAT in FH rats was significantly less than that elicited in SD animals. The present results are supportive of the view that the responsiveness of serotonergic mechanisms in the CNS of FH rats differs markedly from those in SD animals.

Original languageEnglish (US)
Pages (from-to)489-492
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume22
Issue number3
DOIs
StatePublished - Mar 1985

Keywords

  • 5-Methoxy-N,N-dimethyltryptamine
  • 8-OH-DPAT
  • Fawn-Hooded rats
  • Hyperthermia
  • Hypothermia
  • Quipazine
  • Wet dog shakes

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

Fingerprint

Dive into the research topics of 'Altered responses to serotonergic agents in Fawn-Hooded rats'. Together they form a unique fingerprint.

Cite this