Abstract
Excretion of urinary modified nucleosides is frequently elevated in patients with oncogenic disease. Increases of urinary pseudouridine excretion are now demonstrated in patients with a variety of brain tumors. The potential use of urinary modified base excretion as a cancer marker is discussed and possible sources of the elevated nucleosides are detailed. The specific steps in RNA metabolism that result in increased levels of RNA nucleoside excretion are poorly understood. This knowledge will be necessary to understand the molecular mechanism and the clinical significance of urinary nucleoside excretion in treatment and diagnosis of oncogenic disease.
Original language | English (US) |
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Pages (from-to) | 353-368 |
Number of pages | 16 |
Journal | Molecular and Chemical Neuropathology |
Volume | 21 |
Issue number | 2-3 |
DOIs | |
State | Published - Feb 1994 |
Keywords
- RNA
- Urinary nucleosides
- modified nucleosides
- pseudouridine
- tRNA
- tumor markers
- urinary excretion
ASJC Scopus subject areas
- Clinical Neurology
- Molecular Biology
- General Neuroscience