Altered RNA turnover in carcinogenesis - The diagnostic potential of modified base excretion

Christopher C. Marvel*, John Del Rowe, Eric G. Bremer, Joseph R. Moskal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Excretion of urinary modified nucleosides is frequently elevated in patients with oncogenic disease. Increases of urinary pseudouridine excretion are now demonstrated in patients with a variety of brain tumors. The potential use of urinary modified base excretion as a cancer marker is discussed and possible sources of the elevated nucleosides are detailed. The specific steps in RNA metabolism that result in increased levels of RNA nucleoside excretion are poorly understood. This knowledge will be necessary to understand the molecular mechanism and the clinical significance of urinary nucleoside excretion in treatment and diagnosis of oncogenic disease.

Original languageEnglish (US)
Pages (from-to)353-368
Number of pages16
JournalMolecular and Chemical Neuropathology
Volume21
Issue number2-3
DOIs
StatePublished - Feb 1994

Keywords

  • RNA
  • Urinary nucleosides
  • modified nucleosides
  • pseudouridine
  • tRNA
  • tumor markers
  • urinary excretion

ASJC Scopus subject areas

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'Altered RNA turnover in carcinogenesis - The diagnostic potential of modified base excretion'. Together they form a unique fingerprint.

Cite this