Altered task-related modulation of long-range connectivity in children with autism

Ajay S. Pillai*, Danielle McAuliffe, Balaji M. Lakshmanan, Stewart H. Mostofsky, Nathan E. Crone, Joshua B. Ewen

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Functional connectivity differences between children with autism spectrum disorder (ASD) and typically developing children have been described in multiple datasets. However, few studies examine the task-related changes in connectivity in disorder-relevant behavioral paradigms. In this paper, we examined the task-related changes in functional connectivity using EEG and a movement-based paradigm that has behavioral relevance to ASD. Resting-state studies motivated our hypothesis that children with ASD would show a decreased magnitude of functional connectivity during the performance of a motor-control task. Contrary to our initial hypothesis, however, we observed that task-related modulation of functional connectivity in children with ASD was in the direction opposite to that of TDs. The task-related connectivity changes were correlated with clinical symptom scores. Our results suggest that children with ASD may have differences in cortical segregation/integration during the performance of a task, and that part of the differences in connectivity modulation may serve as a compensatory mechanism. Autism Res 2018, 11: 245–257.

Original languageEnglish (US)
Pages (from-to)245-257
Number of pages13
JournalAutism Research
Volume11
Issue number2
DOIs
StatePublished - Feb 2018
Externally publishedYes

Keywords

  • autism
  • connectivity
  • dyspraxia
  • EEG
  • functional connectivity
  • task-related

ASJC Scopus subject areas

  • General Neuroscience
  • Clinical Neurology
  • Genetics(clinical)

Fingerprint

Dive into the research topics of 'Altered task-related modulation of long-range connectivity in children with autism'. Together they form a unique fingerprint.

Cite this