Altered thyroid hormone levels in bacterial sepsis: The role of nutritional adequacy

D. A. Richmand, M. E. Molitch*, T. F. O'Donnell

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Depressed triiodothyronine and elevated reverse triiodothyronine levels are commonly seen in patients with acute and chronic illness and in patients receiving markedly hypocaloric diets. To investigate the role of nutritional adequacy in causing the altered thyroid hormone levels found in severe illness, we studied patients with bacterial sepsis who were receiving a variety of nutritional regimens. Thirteen patients received only 5% dextrose in water (600–1000 kcal/day), 7 of whom were in shock. Seven patients received total parenteral nutrition (2500–3500 kcal/day). Analysis of thyroid hormone levels in these groups and in controls shows that a large component of the alteration in thyroid hormone levels found in patients with severe illness is due to the caloric deprivation associated with such severe illness.

Original languageEnglish (US)
Pages (from-to)936-942
Number of pages7
JournalMetabolism: Clinical and Experimental
Volume29
Issue number10
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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