Alternative Candida albicans lifestyles: Growth on surfaces

Carol A. Kumamoto*, Marcelo D. Vinces

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Candida albicans, an opportunistic fungal pathogen, causes a wide variety of human diseases such as oral thrush and disseminated candidiasis. Many aspects of C. albicans physiology have been studied during liquid growth, but in its natural environment, the gastrointestinal tract of a mammalian host, the organism associates with surfaces. Growth on a surface triggers several behaviors, such as biofilm formation, invasion, and thigmotropism, that are important for infection. Recent discoveries have identified factors that regulate these behaviors and revealed the importance of these behaviors for pathogenesis.

Original languageEnglish (US)
Pages (from-to)113-133
Number of pages21
JournalAnnual Review of Microbiology
Volume59
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Biofilm
  • Hyphae
  • Invasive growth
  • Thigmotropism
  • Tissue invasion

ASJC Scopus subject areas

  • Microbiology

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