Alternative RNA splicing and cancer

Sali Liu, Chonghui Cheng*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

57 Scopus citations

Abstract

Alternative splicing of pre-messenger RNA (mRNA) is a fundamental mechanism by which a gene can give rise to multiple distinct mRNA transcripts, yielding protein isoforms with different, even opposing, functions. With the recognition that alternative splicing occurs in nearly all human genes, its relationship with cancer-associated pathways has emerged as a rapidly growing field. In this review, we summarize recent findings that have implicated the critical role of alternative splicing in cancer and discuss current understandings of the mechanisms underlying dysregulated alternative splicing in cancer cells.

Original languageEnglish (US)
Pages (from-to)547-566
Number of pages20
JournalWiley Interdisciplinary Reviews: RNA
Volume4
Issue number5
DOIs
StatePublished - Sep 2013

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology

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