Alternative Splicing in the Nervous System

J. Y. Wu*, J. A. Potashkin

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

The sequencing of the human genome has revealed that the number of protein-coding genes is far fewer than initially predicted based on phenotypic diversity. This implies that posttranscriptional processing of RNA transcripts plays a more important role in generating genetic diversity than previously anticipated. One of the most powerful mechanisms contributing to transcript diversity is alternative pre-mRNA splicing. This process of generating multiple mRNAs from single pre-mRNA transcripts occurs at the highest frequency in the nervous system. This article focuses on the important role splicing plays in the nervous system and the evidence that mutations that affect splicing often lead to neurological disease.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages245-251
Number of pages7
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Alternative splicing
  • Ataxia
  • Frontotemporal dementia and parkinsonism linked to chromosome 17
  • Gene expression
  • Muscular dystrophy
  • Myotonic dystrophy
  • Neurodegeneration
  • Prader-Willi syndrome
  • RNA
  • Spinal muscular atrophy

ASJC Scopus subject areas

  • Neuroscience(all)

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