Alternative strategies of posttransplant influenza vaccination in adult solid organ transplant recipients

Zaid Haddadin*, Karen Krueger, Lora D. Thomas, Edgar T. Overton, Michael Ison, Natasha Halasa

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

23 Scopus citations


Solid organ transplant (SOT) recipients are at increased risk of influenza disease and associated complications. The mainstay of prevention is the annual standard-dose influenza vaccine, as studies showed decreased influenza-related morbidity and mortality in vaccinated SOT recipients compared to those unvaccinated. Nonetheless, the immune response in this high-risk population is suboptimal compared to healthy individuals. Over the past two decades, several vaccination strategies have been investigated to overcome this inadequate immune response in SOT recipients. Howbeit, the best vaccination strategy and optimal timing of influenza vaccination remain unclear. This review will provide a detailed summary of studies of various influenza vaccination strategies in adult SOT recipients, discussing immunogenicity results, and addressing their limitations and knowledge gaps.

Original languageEnglish (US)
Pages (from-to)938-949
Number of pages12
JournalAmerican Journal of Transplantation
Issue number3
StatePublished - Mar 2021


  • clinical research/practice
  • editorial/personal viewpoint
  • immunobiology
  • infection and infectious agents—viral: influenza
  • infectious disease
  • organ transplantation in general
  • preventive healthcare
  • vaccine

ASJC Scopus subject areas

  • Transplantation
  • Pharmacology (medical)
  • Immunology and Allergy


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