Alternative Treatments for Atopic Dermatitis

An Update

Katherine Shi, Peter A Lio*

*Corresponding author for this work

Research output: Contribution to journalReview article

Abstract

Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease in which management with topical anti-inflammatory agents during exacerbations remains the mainstay of treatment. With no cure in sight, a significant proportion of patients elect to incorporate complementary and alternative medicine (CAM) as an adjunct to conventional treatment. Many clinicians find it difficult to provide recommendations as the field covers an extensive number of very disparate therapies, with limited quality evidence to indicate efficacy. Since publication of the last review on this topic in the Journal that compiled and analyzed randomized controlled trials (RCTs) on CAMs in 2015, several new studies have surfaced. This update aims to aggregate and review these new data. A literature search was conducted in the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Global Resource for EczemA Trials (GREAT) databases for RCTs on complementary and alternative therapies in AD from March 2015 through May 2018, resulting in 15 studies being included in this review. The preliminary results for many treatments such as vitamin E, East Indian Sandalwood Oil (EISO), melatonin, l-histidine, and Manuka honey show positive clinical effects, but there is currently not enough evidence to recommend their use in AD therapy. Future investigative efforts should focus on reproducing some of these studies with a larger sample size whose clinical characteristics and demographics are more reflective of the general AD population, and standardizing the process to produce reliable data.

Original languageEnglish (US)
Pages (from-to)251-266
Number of pages16
JournalAmerican Journal of Clinical Dermatology
Volume20
Issue number2
DOIs
StatePublished - Apr 1 2019

Fingerprint

Atopic Dermatitis
Complementary Therapies
Randomized Controlled Trials
Therapeutics
Honey
Eczema
Melatonin
Vitamin E
Skin Diseases
Histidine
PubMed
Sample Size
Publications
Anti-Inflammatory Agents
Demography
Databases
Population

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Alternative Treatments for Atopic Dermatitis: An Update",
abstract = "Atopic dermatitis (AD) is a chronic pruritic inflammatory skin disease in which management with topical anti-inflammatory agents during exacerbations remains the mainstay of treatment. With no cure in sight, a significant proportion of patients elect to incorporate complementary and alternative medicine (CAM) as an adjunct to conventional treatment. Many clinicians find it difficult to provide recommendations as the field covers an extensive number of very disparate therapies, with limited quality evidence to indicate efficacy. Since publication of the last review on this topic in the Journal that compiled and analyzed randomized controlled trials (RCTs) on CAMs in 2015, several new studies have surfaced. This update aims to aggregate and review these new data. A literature search was conducted in the PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and Global Resource for EczemA Trials (GREAT) databases for RCTs on complementary and alternative therapies in AD from March 2015 through May 2018, resulting in 15 studies being included in this review. The preliminary results for many treatments such as vitamin E, East Indian Sandalwood Oil (EISO), melatonin, l-histidine, and Manuka honey show positive clinical effects, but there is currently not enough evidence to recommend their use in AD therapy. Future investigative efforts should focus on reproducing some of these studies with a larger sample size whose clinical characteristics and demographics are more reflective of the general AD population, and standardizing the process to produce reliable data.",
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Alternative Treatments for Atopic Dermatitis : An Update. / Shi, Katherine; Lio, Peter A.

In: American Journal of Clinical Dermatology, Vol. 20, No. 2, 01.04.2019, p. 251-266.

Research output: Contribution to journalReview article

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