Alveolar Macrophages

Nikita Joshi, James McCauley Walter, Alexander Misharin*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.

Original languageEnglish (US)
Pages (from-to)86-90
Number of pages5
JournalCellular Immunology
Volume330
DOIs
StatePublished - Aug 1 2018

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Alveolar Macrophages
Lung
Surface-Active Agents
Macrophages
Health

Keywords

  • Alveolar macrophages
  • Macrophages

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.",
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Alveolar Macrophages. / Joshi, Nikita; Walter, James McCauley; Misharin, Alexander.

In: Cellular Immunology, Vol. 330, 01.08.2018, p. 86-90.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Alveolar Macrophages

AU - Joshi, Nikita

AU - Walter, James McCauley

AU - Misharin, Alexander

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.

AB - Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.

KW - Alveolar macrophages

KW - Macrophages

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DO - 10.1016/j.cellimm.2018.01.005

M3 - Article

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