Abstract
Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 86-90 |
| Number of pages | 5 |
| Journal | Cellular Immunology |
| Volume | 330 |
| DOIs | |
| State | Published - Aug 1 2018 |
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Keywords
- Alveolar macrophages
- Macrophages
ASJC Scopus subject areas
- Immunology
Cite this
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Alveolar Macrophages. / Joshi, Nikita; Walter, James McCauley; Misharin, Alexander.
In: Cellular Immunology, Vol. 330, 01.08.2018, p. 86-90.Research output: Contribution to journal › Article
TY - JOUR
T1 - Alveolar Macrophages
AU - Joshi, Nikita
AU - Walter, James McCauley
AU - Misharin, Alexander
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.
AB - Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.
KW - Alveolar macrophages
KW - Macrophages
UR - http://www.scopus.com/inward/record.url?scp=85040694129&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85040694129&partnerID=8YFLogxK
U2 - 10.1016/j.cellimm.2018.01.005
DO - 10.1016/j.cellimm.2018.01.005
M3 - Article
C2 - 29370889
AN - SCOPUS:85040694129
VL - 330
SP - 86
EP - 90
JO - Cellular Immunology
JF - Cellular Immunology
SN - 0008-8749
ER -