@article{a0ffd4c90ca141cb81f1f12d4f4c9e22,
title = "Alveolar Macrophages",
abstract = "Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.",
keywords = "Alveolar macrophages, Macrophages",
author = "Nikita Joshi and Walter, {James M.} and Misharin, {Alexander V.}",
note = "Funding Information: James M Walter is supported by Northwestern University{\textquoteright}s Lung Sciences Training Program 5T32HL076139-14 and Northwestern University {\textquoteright}s Dixon Young Investigator Translational Research Grant. Alexander V Misharin is supported by NIH NHLBI 1R56HL135124-01 , BD Bioscience Immunology Research Grant and by the Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program under Award W81XWH-15-1-0215. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. ",
year = "2018",
month = aug,
doi = "10.1016/j.cellimm.2018.01.005",
language = "English (US)",
volume = "330",
pages = "86--90",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
}