Alveolar Macrophages

Nikita Joshi; James M. Walter; Alexander V. Misharin

doi:10.1016/j.cellimm.2018.01.005

Alveolar Macrophages

Nikita Joshi, James M. Walter, Alexander V. Misharin^*

^*Corresponding author for this work

Medicine, Pulmonary Division

Research output: Contribution to journal › Article › peer-review

232 Scopus citations

Abstract

Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.

Original language	English (US)
Pages (from-to)	86-90
Number of pages	5
Journal	Cellular Immunology
Volume	330
DOIs	https://doi.org/10.1016/j.cellimm.2018.01.005
State	Published - Aug 2018

Funding

James M Walter is supported by Northwestern University’s Lung Sciences Training Program 5T32HL076139-14 and Northwestern University ’s Dixon Young Investigator Translational Research Grant. Alexander V Misharin is supported by NIH NHLBI 1R56HL135124-01 , BD Bioscience Immunology Research Grant and by the Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program under Award W81XWH-15-1-0215. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense. James M Walter is supported by Northwestern University's Lung Sciences Training Program 5T32HL076139-14 and Northwestern University's Dixon Young Investigator Translational Research Grant. Alexander V Misharin is supported by NIH NHLBI 1R56HL135124-01, BD Bioscience Immunology Research Grant and by the Office of the Assistant Secretary of Defense for Health Affairs, through the Peer Reviewed Medical Research Program under Award W81XWH-15-1-0215. Opinions, interpretations, conclusions and recommendations are those of the author and are not necessarily endorsed by the Department of Defense.

Keywords

Alveolar macrophages
Macrophages

ASJC Scopus subject areas

Immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.cellimm.2018.01.005

Cite this

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abstract = "Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.",

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year = "2018",

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doi = "10.1016/j.cellimm.2018.01.005",

language = "English (US)",

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AU - Misharin, Alexander V.

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AB - Alveolar macrophages are the most abundant innate immune cells in the distal lung parenchyma, located on the luminal surface of the alveolar space. They are the first to encounter incoming pathogens and pollutants and to help orchestrate the initiation and resolution of the immune response in the lung. Similar to other tissue-resident macrophages, alveolar macrophages also perform non-immune, tissue-specific, homeostatic functions, most notably clearance of surfactant. In this review we will discuss how ontogeny and local lung environment shape the role of alveolar macrophages in health and disease.

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Alveolar Macrophages

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

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