Alzheimer's disease and β-amyloid

A. H. Schmaier, W. Van Nostrand, B. A. Yankner, M. M. Mesulam

Research output: Contribution to journalLetterpeer-review


To the Editor: The report by Yankner and Mesulam (Dec. 26 issue)1 on β-amyloid and the pathogenesis of Alzheimer's disease is a timely and comprehensive presentation of the fascinating genetics and protein biochemistry of this common, devastating illness. However, some modification of their hypothesis for the mechanism of neuronal degeneration should be considered. According to the authors, the ability of the β-amyloid peptide to bind the cellular receptors required to clear the serpin protease inhibitor—enzyme complexes2 could result in long-term proteolytic damage from the uncleared proteases and may be a direct cause of neuronal degeneration in Alzheimer's disease. This interpretation.

Original languageEnglish (US)
Pages (from-to)1292-1293
Number of pages2
JournalNew England Journal of Medicine
Issue number19
StatePublished - May 7 1992

ASJC Scopus subject areas

  • General Medicine


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