American thyroid association guide to investigating thyroid hormone economy and action in rodent and cell models

Antonio C. Bianco*, Grant Anderson, Douglas Forrest, Valerie Anne Galton, Balázs Gereben, Brian W. Kim, Peter A. Kopp, Xiao Hui Liao, Maria Jesus Obregon, Robin P. Peeters, Samuel Refetoff, David S. Sharlin, Warner S. Simonides, Roy E. Weiss, Graham R. Williams

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

136 Scopus citations


Background: An in-depth understanding of the fundamental principles that regulate thyroid hormone homeostasis is critical for the development of new diagnostic and treatment approaches for patients with thyroid disease. Summary: Important clinical practices in use today for the treatment of patients with hypothyroidism, hyperthyroidism, or thyroid cancer are the result of laboratory discoveries made by scientists investigating the most basic aspects of thyroid structure and molecular biology. In this document, a panel of experts commissioned by the American Thyroid Association makes a series of recommendations related to the study of thyroid hormone economy and action. These recommendations are intended to promote standardization of study design, which should in turn increase the comparability and reproducibility of experimental findings. Conclusions: It is expected that adherence to these recommendations by investigators in the field will facilitate progress towards a better understanding of the thyroid gland and thyroid hormone dependent processes.

Original languageEnglish (US)
Pages (from-to)88-168
Number of pages81
Issue number1
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism


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