Amiloride in the Treatment of Lithium-Induced Diabetes Insipidus

Paul R. Billings, Elie Cogan, Maurice Abramow, Richard A. Sherman, John A. Walker, Robert P. Eisinger, Daniel C. Batlle, Alisa Von Riotte, Mosies Gaviria, Marlene Grupp

Research output: Contribution to journalLetterpeer-review

4 Scopus citations


To the Editor: Although the exact mechanism of the antidiuresis demonstrated by Batlle et al. (Feb. 14 issue)1 is unclear, their suggested treatment protocol for lithium-induced diabetes insipidus seems effective. It may have practical and theoretical advantages over approaches using free-water deprivation or thiazide diuretics. Amiloride has a broad range of biologic effects and inhibits many cation-transport systems.2 With lithium-loaded human erythrocytes used as a model system, it has recently been demonstrated that a single genetic locus called “amiloride inhibitable lithium transport” (AILT) modifies lithium movements across these cells3 (and unpublished data). Nine per cent of the general population of.

Original languageEnglish (US)
Pages (from-to)1575-1577
Number of pages3
JournalNew England Journal of Medicine
Issue number24
StatePublished - Jun 13 1985

ASJC Scopus subject areas

  • Medicine(all)


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