Abstract
Recent structural and biochemical experiments indicate that bacterial elongation factor Tu and the ribosomal A-site show specificity for both the amino acid and the tRNA portions of their aminoacyl-tRNA (aa-tRNA) substrates. These data are inconsistent with the traditional view that tRNAs are generic adaptors in translation. We hypothesize that each tRNA sequence has co-evolved with its cognate amino acid, such that all aa-tRNAs are translated uniformly.
Original language | English (US) |
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Pages (from-to) | 659-665 |
Number of pages | 7 |
Journal | Trends in Biochemical Sciences |
Volume | 30 |
Issue number | 12 |
DOIs | |
State | Published - Dec 2005 |
Funding
This work was supported by National Institutes of Health Grant GM37552 to O.C.U.
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology