Amino acid specificity in translation

Taraka Dale, Olke C. Uhlenbeck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

61 Scopus citations


Recent structural and biochemical experiments indicate that bacterial elongation factor Tu and the ribosomal A-site show specificity for both the amino acid and the tRNA portions of their aminoacyl-tRNA (aa-tRNA) substrates. These data are inconsistent with the traditional view that tRNAs are generic adaptors in translation. We hypothesize that each tRNA sequence has co-evolved with its cognate amino acid, such that all aa-tRNAs are translated uniformly.

Original languageEnglish (US)
Pages (from-to)659-665
Number of pages7
JournalTrends in Biochemical Sciences
Issue number12
StatePublished - Dec 2005

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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