Amino acids and derivatives, a new treatment of chronic heart failure?

Valentina Carubelli, Anna Isotta Castrini, Valentina Lazzarini, Mihai Gheorghiade, Marco Metra*, Carlo Lombardi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

26 Scopus citations


Amino acids play a key role in multiple cellular processes. Amino acids availability is reduced in patients with heart failure (HF) with deleterious consequences on cardiac and whole-body metabolism. Several metabolic abnormalities have been identified in the failing heart, and many of them lead to an increased need of amino acids. Recently, several clinical trials have been conducted to demonstrate the benefits of amino acids supplementation in patients with HF. Although they have shown an improvement of exercise tolerance and, in some cases, of left ventricular function, they have many limitations, namely small sample size, differences in patients’ characteristics and nutritional supplementations, and lack of data regarding outcomes. Moreover recent data suggest that a multi-nutritional approach, including also antioxidants, vitamins, and metals, may be more effective. Larger trials are needed to ascertain safety, efficacy, and impact on prognosis of such an approach in HF.

Original languageEnglish (US)
Pages (from-to)39-51
Number of pages13
JournalHeart Failure Reviews
Issue number1
StatePublished - Jan 2014


  • Amino acids
  • Chronic heart failure
  • Essential amino acids
  • Heart failure
  • Nutrition
  • Supplementation

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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