(Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators

Richard B. Silverman; Madhavi K. Vadnere

doi:10.1016/0045-2068(87)90028-9

(Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators

Richard B. Silverman^*, Madhavi K. Vadnere

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

(Aminoalkyl)trimethylgermanes, Me₃Ge(CH₂)_nNH₃⁺ (n = 1-3), are synthesized and shown to be mechanism-based irreversible inactivators of mitochondrial monoamine oxidase. At least two different adducts are formed by the three compounds. These are the first mechanism-based organogermanium inactivators of any specific enzyme.

Original language	English (US)
Pages (from-to)	328-332
Number of pages	5
Journal	Bioorganic Chemistry
Volume	15
Issue number	3
DOIs	https://doi.org/10.1016/0045-2068(87)90028-9
State	Published - Sep 1987

ASJC Scopus subject areas

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

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title = "(Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators",

abstract = "(Aminoalkyl)trimethylgermanes, Me3Ge(CH2)nNH3+ (n = 1-3), are synthesized and shown to be mechanism-based irreversible inactivators of mitochondrial monoamine oxidase. At least two different adducts are formed by the three compounds. These are the first mechanism-based organogermanium inactivators of any specific enzyme.",

author = "Silverman, {Richard B.} and Vadnere, {Madhavi K.}",

year = "1987",

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AB - (Aminoalkyl)trimethylgermanes, Me3Ge(CH2)nNH3+ (n = 1-3), are synthesized and shown to be mechanism-based irreversible inactivators of mitochondrial monoamine oxidase. At least two different adducts are formed by the three compounds. These are the first mechanism-based organogermanium inactivators of any specific enzyme.

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