(Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators: A new class of monoamine oxidase inactivators

Richard B. Silverman*, Madhavi K. Vadnere

*Corresponding author for this work

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

(Aminoalkyl)trimethylgermanes, Me3Ge(CH2)nNH3+ (n = 1-3), are synthesized and shown to be mechanism-based irreversible inactivators of mitochondrial monoamine oxidase. At least two different adducts are formed by the three compounds. These are the first mechanism-based organogermanium inactivators of any specific enzyme.

Original languageEnglish (US)
Pages (from-to)328-332
Number of pages5
JournalBioorganic Chemistry
Volume15
Issue number3
DOIs
StatePublished - Sep 1987

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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