TY - JOUR
T1 - (Aminoalkyl)trimethylgermanes, the first organogermanium mechanism-based enzyme inactivators
T2 - A new class of monoamine oxidase inactivators
AU - Silverman, Richard B.
AU - Vadnere, Madhavi K.
N1 - Funding Information:
We are grateful to the National Institutes of Health (Grant GM 32634) for financial support. R.B.S. is a National Institutes of Health Research Career Development Awardee (1982-1987).
PY - 1987/9
Y1 - 1987/9
N2 - (Aminoalkyl)trimethylgermanes, Me3Ge(CH2)nNH3+ (n = 1-3), are synthesized and shown to be mechanism-based irreversible inactivators of mitochondrial monoamine oxidase. At least two different adducts are formed by the three compounds. These are the first mechanism-based organogermanium inactivators of any specific enzyme.
AB - (Aminoalkyl)trimethylgermanes, Me3Ge(CH2)nNH3+ (n = 1-3), are synthesized and shown to be mechanism-based irreversible inactivators of mitochondrial monoamine oxidase. At least two different adducts are formed by the three compounds. These are the first mechanism-based organogermanium inactivators of any specific enzyme.
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U2 - 10.1016/0045-2068(87)90028-9
DO - 10.1016/0045-2068(87)90028-9
M3 - Article
AN - SCOPUS:0023633219
VL - 15
SP - 328
EP - 332
JO - Bioorganic Chemistry
JF - Bioorganic Chemistry
SN - 0045-2068
IS - 3
ER -