Aminonucleoside Nephrosis in PRO/Re Mice

Yashpal S. Kanwar; Jose R. Manaligod; Cecil A. Krakower

doi:10.3181/00379727-155-39802

Aminonucleoside Nephrosis in PRO/Re Mice

Yashpal S. Kanwar, Jose R. Manaligod, Cecil A. Krakower

Pathology

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5 Scopus citations

Abstract

Administration of aminonu-cleoside of puromycin to PRO/Re strain mice resulted in biochemical and renal glomerular alterations. The biochemical changes included hypoalbuminemia, hyper-alphaglobulinemia, hypercholesterolemia, and azotemia. Morphologically, there was approximation of visceral epithelial foot processes, intracytoplasmic vacuolization or percellular channel formation, and immense deposition of moderately electron-dense material in the subendothelial regions and lumens of glomerular capillaries. Attempts to induce similar changes in either of the parental and in other nonparental strains of mice of diverse genetic origins were unsuccessful.

Original language	English (US)
Pages (from-to)	339-345
Number of pages	7
Journal	Proceedings of the Society for Experimental Biology and Medicine
Volume	155
Issue number	3
DOIs	https://doi.org/10.3181/00379727-155-39802
State	Published - Jul 1977

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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title = "Aminonucleoside Nephrosis in PRO/Re Mice",

abstract = "Administration of aminonu-cleoside of puromycin to PRO/Re strain mice resulted in biochemical and renal glomerular alterations. The biochemical changes included hypoalbuminemia, hyper-alphaglobulinemia, hypercholesterolemia, and azotemia. Morphologically, there was approximation of visceral epithelial foot processes, intracytoplasmic vacuolization or percellular channel formation, and immense deposition of moderately electron-dense material in the subendothelial regions and lumens of glomerular capillaries. Attempts to induce similar changes in either of the parental and in other nonparental strains of mice of diverse genetic origins were unsuccessful.",

author = "Kanwar, {Yashpal S.} and Manaligod, {Jose R.} and Krakower, {Cecil A.}",

note = "Funding Information: This work was supported in part by NIH Grant No. HL01623. 2 ",

year = "1977",

month = jul,

doi = "10.3181/00379727-155-39802",

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T1 - Aminonucleoside Nephrosis in PRO/Re Mice

AU - Kanwar, Yashpal S.

AU - Manaligod, Jose R.

AU - Krakower, Cecil A.

N1 - Funding Information: This work was supported in part by NIH Grant No. HL01623. 2

PY - 1977/7

Y1 - 1977/7

N2 - Administration of aminonu-cleoside of puromycin to PRO/Re strain mice resulted in biochemical and renal glomerular alterations. The biochemical changes included hypoalbuminemia, hyper-alphaglobulinemia, hypercholesterolemia, and azotemia. Morphologically, there was approximation of visceral epithelial foot processes, intracytoplasmic vacuolization or percellular channel formation, and immense deposition of moderately electron-dense material in the subendothelial regions and lumens of glomerular capillaries. Attempts to induce similar changes in either of the parental and in other nonparental strains of mice of diverse genetic origins were unsuccessful.

AB - Administration of aminonu-cleoside of puromycin to PRO/Re strain mice resulted in biochemical and renal glomerular alterations. The biochemical changes included hypoalbuminemia, hyper-alphaglobulinemia, hypercholesterolemia, and azotemia. Morphologically, there was approximation of visceral epithelial foot processes, intracytoplasmic vacuolization or percellular channel formation, and immense deposition of moderately electron-dense material in the subendothelial regions and lumens of glomerular capillaries. Attempts to induce similar changes in either of the parental and in other nonparental strains of mice of diverse genetic origins were unsuccessful.

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JO - Proceedings of the Society for Experimental Biology and Medicine

JF - Proceedings of the Society for Experimental Biology and Medicine

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Aminonucleoside Nephrosis in PRO/Re Mice

Abstract

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