Aminonucleoside Nephrosis in PRO/Re Mice

Yashpal S. Kanwar, Jose R. Manaligod, Cecil A. Krakower

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Administration of aminonu-cleoside of puromycin to PRO/Re strain mice resulted in biochemical and renal glomerular alterations. The biochemical changes included hypoalbuminemia, hyper-alphaglobulinemia, hypercholesterolemia, and azotemia. Morphologically, there was approximation of visceral epithelial foot processes, intracytoplasmic vacuolization or percellular channel formation, and immense deposition of moderately electron-dense material in the subendothelial regions and lumens of glomerular capillaries. Attempts to induce similar changes in either of the parental and in other nonparental strains of mice of diverse genetic origins were unsuccessful.

Original languageEnglish (US)
Pages (from-to)339-345
Number of pages7
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number3
StatePublished - Jul 1977

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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