Amphiphilic dendrimers: Novel self-assembling vectors for efficient gene delivery

Derk Joester; Myriam Losson; Raphaël Pugin; Harry Heinzelmann; Elke Walter; Hans P. Merkle; François Diederich

doi:10.1002/anie.200250284

Amphiphilic dendrimers: Novel self-assembling vectors for efficient gene delivery

Derk Joester, Myriam Losson, Raphaël Pugin, Harry Heinzelmann, Elke Walter, Hans P. Merkle, François Diederich^*

^*Corresponding author for this work

Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

149 Scopus citations

Abstract

A sharp maximum in the structure-activity relationship, a surprisingly strong influence of the hydrophobic part on DNA binding and transport, and an unusual serum effect on relative transfection activities were found in preliminary biological data on a series of four amphiphilic dendrimers designed as transfection agents. The lowest generation dendrimer 1 was found to be the most active.

Original language	English (US)
Pages (from-to)	1486-1490
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	42
Issue number	13
DOIs	https://doi.org/10.1002/anie.200250284
State	Published - Apr 4 2003

Keywords

Amphiphiles
Cross-coupling
DNA recognition
Dendrimers
Gene transfection

ASJC Scopus subject areas

General Chemistry
Catalysis

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10.1002/anie.200250284

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abstract = "A sharp maximum in the structure-activity relationship, a surprisingly strong influence of the hydrophobic part on DNA binding and transport, and an unusual serum effect on relative transfection activities were found in preliminary biological data on a series of four amphiphilic dendrimers designed as transfection agents. The lowest generation dendrimer 1 was found to be the most active.",

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AU - Heinzelmann, Harry

AU - Walter, Elke

AU - Merkle, Hans P.

AU - Diederich, François

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AB - A sharp maximum in the structure-activity relationship, a surprisingly strong influence of the hydrophobic part on DNA binding and transport, and an unusual serum effect on relative transfection activities were found in preliminary biological data on a series of four amphiphilic dendrimers designed as transfection agents. The lowest generation dendrimer 1 was found to be the most active.

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KW - Cross-coupling

KW - DNA recognition

KW - Dendrimers

KW - Gene transfection

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Amphiphilic dendrimers: Novel self-assembling vectors for efficient gene delivery

Abstract

Keywords

ASJC Scopus subject areas

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