Amphiphilic dendrimers: Novel self-assembling vectors for efficient gene delivery

Derk Joester, Myriam Losson, Raphaël Pugin, Harry Heinzelmann, Elke Walter, Hans P. Merkle, François Diederich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

139 Scopus citations

Abstract

A sharp maximum in the structure-activity relationship, a surprisingly strong influence of the hydrophobic part on DNA binding and transport, and an unusual serum effect on relative transfection activities were found in preliminary biological data on a series of four amphiphilic dendrimers designed as transfection agents. The lowest generation dendrimer 1 was found to be the most active.

Original languageEnglish (US)
Pages (from-to)1486-1490
Number of pages5
JournalAngewandte Chemie - International Edition
Volume42
Issue number13
DOIs
StatePublished - Apr 4 2003

Keywords

  • Amphiphiles
  • Cross-coupling
  • DNA recognition
  • Dendrimers
  • Gene transfection

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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