Amplification of acute focal ischemic deficit by narcotics

Jordan Dubow, Richard A. Bernstein

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Introduction: This article describes two patients with major ischemic stroke symptoms who had extremely small areas of acute brain infarction, suggestive of acute intrahemispheric diaschisis. Both patients were using narcotic analgesics during their stroke, and in both cases the clinical deficits improved dramatically with naloxone. Discussion: We postulate that the narcotics amplified the ischemic stroke symptoms and that this effect was antagonized by naloxone. Conclusion: This suggests that the opiate system may be involved in the process of intrahemispheric diaschisis.

Original languageEnglish (US)
Pages (from-to)427-429
Number of pages3
JournalNeurocritical Care
Issue number3
StatePublished - Jun 1 2008


  • Acute ischemic stroke
  • Naloxone
  • Opiates

ASJC Scopus subject areas

  • Clinical Neurology
  • Critical Care and Intensive Care Medicine


Dive into the research topics of 'Amplification of acute focal ischemic deficit by narcotics'. Together they form a unique fingerprint.

Cite this